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    megf6b multiple EGF-like-domains 6b [ Danio rerio (zebrafish) ]

    Gene ID: 557764, updated on 17-Aug-2024

    Summary

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    Official Symbol
    megf6bprovided by ZNC
    Official Full Name
    multiple EGF-like-domains 6bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-101112-3
    See related
    Ensembl:ENSDARG00000074808 AllianceGenome:ZFIN:ZDB-GENE-101112-3
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable calcium ion binding activity. Is expressed in apical ectodermal ridge pectoral fin bud; head; mouth; and notochord. Orthologous to human MEGF6 (multiple EGF like domains 6). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See megf6b in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (41711150..41832160, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (41099628..41219758, complement)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene parkinson protein 7 Neighboring gene potassium voltage-gated channel subfamily A regulatory beta subunit 2a Neighboring gene aldo-keto reductase family 7, member A3 (aflatoxin aldehyde reductase) Neighboring gene MRT4 homolog, ribosome maturation factor Neighboring gene intermediate filament family orphan 2b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A role for the MEGF6 gene in predisposition to osteoporosis. Teerlink CC, et al. Ann Hum Genet, 2021 Mar. PMID 33026655, Free PMC Article
    2. Highly Efficient CRISPR-Cas9-Based Methods for Generating Deletion Mutations and F0 Embryos that Lack Gene Function in Zebrafish. Hoshijima K, et al. Dev Cell, 2019 Dec 2. PMID 31708433, Free PMC Article
    3. Ikzf1 regulates embryonic T lymphopoiesis via Ccr9 and Irf4 in zebrafish. Huang Y, et al. J Biol Chem, 2019 Nov 1. PMID 31511326, Free PMC Article
    4. Female Sex Development and Reproductive Duct Formation Depend on Wnt4a in Zebrafish. Kossack ME, et al. Genetics, 2019 Jan. PMID 30446521, Free PMC Article
    5. In vivo protein trapping produces a functional expression codex of the vertebrate proteome. Clark KJ, et al. Nat Methods, 2011 Jun. PMID 21552255, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables scavenger receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within caudal fin morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within ossification involved in bone maturation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in system development IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    multiple epidermal growth factor-like domains protein 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      41711150..41832160 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021479907.1 → XP_021335582.1  multiple epidermal growth factor-like domains protein 6 isoform X3

      UniProtKB/TrEMBL
      A0A8M9PVQ9
      Conserved Domains (3) summary
      pfam07546
      Location:33 → 102
      EMI; EMI domain
      pfam14670
      Location:445 → 480
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl00057
      Location:308 → 350
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    2. XM_021479906.1 → XP_021335581.1  multiple epidermal growth factor-like domains protein 6 isoform X2

      UniProtKB/TrEMBL
      A0A8M9QIB9
      Conserved Domains (3) summary
      pfam07546
      Location:33 → 102
      EMI; EMI domain
      pfam14670
      Location:445 → 480
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl00057
      Location:308 → 350
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    3. XM_009306294.3 → XP_009304569.1  multiple epidermal growth factor-like domains protein 6 isoform X1

      UniProtKB/TrEMBL
      A0A8M3B4A3
      Related
      ENSDARP00000101342.4, ENSDART00000109204.5
      Conserved Domains (3) summary
      pfam07546
      Location:33 → 102
      EMI; EMI domain
      pfam14670
      Location:445 → 480
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl00057
      Location:308 → 350
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    Nucleotide Protein
    Heading Accession and Version

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