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    casp10 caspase 10, apoptosis-related cysteine peptidase [ Danio rerio (zebrafish) ]

    Gene ID: 557302, updated on 27-Mar-2024

    Summary

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    Official Symbol
    casp10provided by ZNC
    Official Full Name
    caspase 10, apoptosis-related cysteine peptidaseprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070608-2
    See related
    Ensembl:ENSDARG00000070272 AllianceGenome:ZFIN:ZDB-GENE-070608-2
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    casp8l2
    Summary
    Predicted to enable cysteine-type endopeptidase activity involved in apoptotic signaling pathway; cysteine-type endopeptidase activity involved in execution phase of apoptosis; and death effector domain binding activity. Predicted to be involved in activation of cysteine-type endopeptidase activity involved in apoptotic process and apoptotic process. Predicted to act upstream of or within proteolysis and regulation of apoptotic process. Predicted to be active in cytoplasm. Is expressed in floor plate; intestinal bulb; muscle cell; and pharyngeal arch. Human ortholog(s) of this gene implicated in several diseases, including autoimmune lymphoproliferative syndrome (multiple); breast cancer; endocrine gland cancer (multiple); esophagus adenocarcinoma; and non-Hodgkin lymphoma. Orthologous to several human genes including CASP10 (caspase 10). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See casp10 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (1339175..1358686)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (1337264..1355821)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene disintegrin and metalloproteinase domain-containing protein 23-like Neighboring gene chemerin chemokine-like receptor 2 Neighboring gene protein kinase, interferon-inducible double stranded RNA dependent activator Neighboring gene oxysterol binding protein-like 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Conservation of structure and function in vertebrate c-FLIP proteins despite rapid evolutionary change. Sakamaki K, et al. Biochem Biophys Rep, 2015 Sep. PMID 29124180, Free PMC Article
    2. Early developmental exposure to pentachlorophenol causes alterations on mRNA expressions of caspase protease family in zebrafish embryos. Zhao J, et al. Chemosphere, 2017 Aug. PMID 28402832
    3. Characterization of the caspase family in zebrafish. Spead O, et al. PLoS One, 2018. PMID 29791492, Free PMC Article
    4. Edwardsiella tarda-Induced Inhibition of Apoptosis: A Strategy for Intracellular Survival. Zhou ZJ, et al. Front Cell Infect Microbiol, 2016. PMID 27471679, Free PMC Article
    5. Zebrafish Oxr1a Knockout Reveals Its Role in Regulating Antioxidant Defenses and Aging. Xu H, et al. Genes (Basel), 2020 Sep 24. PMID 32987694, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type endopeptidase activity involved in apoptotic signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables death effector domain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of neuron apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of CD95 death-inducing signaling complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    caspase-10; caspase-8
    Names
    caspase 8, apoptosis-related cysteine peptidase, like 2
    caspase-8b
    XP_685430.4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      1339175..1358686
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_680338.9 → XP_685430.4  caspase-8

      UniProtKB/TrEMBL
      A0A8N7TEL0, E7EXV8
      Related
      ENSDARP00000024255.8, ENSDART00000014766.9
      Conserved Domains (4) summary
      cd00032
      Location:273 → 515
      CASc; Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide ...
      cd08334
      Location:108 → 190
      DED_Caspase_8_10_r2; Death effector domain, repeat 2, of initator caspases 8 and 10
      cd08792
      Location:11 → 87
      DED_Caspase_8_10_r1; Death effector domain, repeat 1, of initator caspases 8 and 10
      pfam15376
      Location:200 → 256
      DUF4603; Domain of unknown function (DUF4603)
    Nucleotide Protein Strain
    Heading Accession and Version

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