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    prom2 prominin 2 [ Danio rerio (zebrafish) ]

    Gene ID: 556596, updated on 12-Sep-2024

    Summary

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    Official Symbol
    prom2provided by ZNC
    Official Full Name
    prominin 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-080723-16
    See related
    Ensembl:ENSDARG00000039406 AllianceGenome:ZFIN:ZDB-GENE-080723-16
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    prom3; proml3; fd36c02; fo25d03; prominin-3; wu:fd36c02
    Summary
    Predicted to enable cholesterol binding activity. Predicted to be located in microvillus membrane. Predicted to be integral component of membrane. Predicted to be active in several cellular components, including apical plasma membrane; microvillus; and prominosome. Predicted to be integral component of plasma membrane. Orthologous to human PROM2 (prominin 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See prom2 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (28747919..28777120)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (28617434..28644548)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene RNA polymerase I and III subunit C Neighboring gene LIM domain binding 1a Neighboring gene small nucleolar RNA SNORA13 Neighboring gene HPS6 biogenesis of lysosomal organelles complex 2 subunit 3 Neighboring gene NSE4 homolog A, SMC5-SMC6 complex component

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Expression of the zebrafish CD133/prominin1 genes in cellular proliferation zones in the embryonic central nervous system and sensory organs. McGrail M, et al. Dev Dyn, 2010 Jun. PMID 20503380
    2. Transcriptome profile of the sinoatrial ring reveals conserved and novel genetic programs of the zebrafish pacemaker. Minhas R, et al. BMC Genomics, 2021 Oct 2. PMID 34600492, Free PMC Article
    3. Prominins control ciliary length throughout the animal kingdom: New lessons from human prominin-1 and zebrafish prominin-3. Jászai J, et al. J Biol Chem, 2020 May 1. PMID 32201384, Free PMC Article
    4. Characterization of prominin-2, a new member of the prominin family of pentaspan membrane glycoproteins. Fargeas CA, et al. J Biol Chem, 2003 Mar 7. PMID 12514187
    5. Comparative transcriptomic analysis identifies evolutionarily conserved gene products in the vertebrate renal distal convoluted tubule. Sugano Y, et al. Pflugers Arch, 2017 Aug. PMID 28656378

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cholesterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within heart development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microvillus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microvillus membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in prominosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    prominin-2
    Names
    prominin 3
    prominin-like 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001302229.1 → NP_001289158.1  prominin-2 precursor

      See identical proteins and their annotated locations for NP_001289158.1

      Status: PROVISIONAL

      Source sequence(s)
      HQ698925
      UniProtKB/TrEMBL
      V9I0H1
      Related
      ENSDARP00000136497.1, ENSDART00000160176.3
      Conserved Domains (2) summary
      TIGR04527
      Location:156 → 296
      mycoplas_twoTM; two transmembrane protein
      pfam05478
      Location:20 → 797
      Prominin; Prominin

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      28747919..28777120
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068212854.1 → XP_068068955.1  prominin-2 isoform X3

    2. XM_005156934.5 → XP_005156991.1  prominin-2 isoform X2

      UniProtKB/TrEMBL
      A0A8M2B3A2
      Conserved Domains (2) summary
      TIGR04527
      Location:156 → 296
      mycoplas_twoTM; two transmembrane protein
      pfam05478
      Location:20 → 797
      Prominin; Prominin

    3. XM_009307409.4 → XP_009305684.1  prominin-2 isoform X1

      UniProtKB/TrEMBL
      A0A8M3B855, F1Q8X9
      Conserved Domains (2) summary
      TIGR04527
      Location:156 → 296
      mycoplas_twoTM; two transmembrane protein
      pfam05478
      Location:20 → 797
      Prominin; Prominin
    Nucleotide Protein Strain
    Heading Accession and Version

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