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    gramd1a GRAM domain containing 1A [ Danio rerio (zebrafish) ]

    Gene ID: 555994, updated on 17-Aug-2024

    Summary

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    Official Symbol
    gramd1aprovided by ZNC
    Official Full Name
    GRAM domain containing 1Aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-060503-688
    See related
    Ensembl:ENSDARG00000076689 AllianceGenome:ZFIN:ZDB-GENE-060503-688
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fc88h04; si:ch211-225p5.11
    Summary
    Predicted to act upstream of or within lipid transport. Predicted to be located in endoplasmic reticulum membrane and plasma membrane. Predicted to be integral component of membrane. Orthologous to human GRAMD1A (GRAM domain containing 1A). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See gramd1a in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (41905013..41965303, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (41954990..42015285, complement)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC110437997 Neighboring gene sodium channel, voltage-gated, type I, beta a Neighboring gene si:ch211-225p5.8 Neighboring gene PYD and CARD domain containing Neighboring gene caspase a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Regulation of cytochrome P450 expression in a novel liver cell line from zebrafish (Brachydanio rerio). Miranda CL, et al. Arch Biochem Biophys, 1993 Sep. PMID 8373170
    2. Transcriptomic analyses reveal novel genes with sexually dimorphic expression in the zebrafish gonad and brain. Sreenivasan R, et al. PLoS One, 2008 Mar 12. PMID 18335061, Free PMC Article
    3. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cholesterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cholesterol transfer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular sterol transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum-plasma membrane contact site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    GRAM domain-containing protein 1A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      41905013..41965303 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005158262.4 → XP_005158319.1  GRAM domain-containing protein 1A isoform X1

      See identical proteins and their annotated locations for XP_005158319.1

      UniProtKB/TrEMBL
      A0A8M2B566
      Conserved Domains (2) summary
      cd13220
      Location:239 → 332
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam16016
      Location:535 → 682
      DUF4782; Domain of unknown function (DUF4782)

    2. XM_021466992.1 → XP_021322667.1  GRAM domain-containing protein 1A isoform X2

      UniProtKB/TrEMBL
      A0A8M9NZU2
      Conserved Domains (2) summary
      cd13220
      Location:239 → 332
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam16016
      Location:535 → 682
      DUF4782; Domain of unknown function (DUF4782)

    3. XM_021466991.1 → XP_021322666.1  GRAM domain-containing protein 1A isoform X1

      UniProtKB/TrEMBL
      A0A8M2B566
      Conserved Domains (2) summary
      cd13220
      Location:239 → 332
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam16016
      Location:535 → 682
      DUF4782; Domain of unknown function (DUF4782)

    4. XM_678684.9 → XP_683776.6  GRAM domain-containing protein 1A isoform X3

      UniProtKB/TrEMBL
      A0A8N7TCR7
      Conserved Domains (2) summary
      cd13220
      Location:132 → 225
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam16016
      Location:428 → 573
      DUF4782; Domain of unknown function (DUF4782)

    5. XM_005158265.4 → XP_005158322.1  GRAM domain-containing protein 1A isoform X4

      UniProtKB/TrEMBL
      A0A8M2B555
      Related
      ENSDARP00000120012.1, ENSDART00000142648.3
      Conserved Domains (2) summary
      cd13220
      Location:98 → 191
      PH-GRAM_GRAMDC; GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      pfam16016
      Location:394 → 539
      DUF4782; Domain of unknown function (DUF4782)
    Nucleotide Protein Strain
    Heading Accession and Version

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