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    actl6b actin-like 6B [ Danio rerio (zebrafish) ]

    Gene ID: 553775, updated on 2-Nov-2024

    Summary

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    Official Symbol
    actl6bprovided by ZNC
    Official Full Name
    actin-like 6Bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050522-191
    See related
    Ensembl:ENSDARG00000034107 AllianceGenome:ZFIN:ZDB-GENE-050522-191
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:110167
    Summary
    Predicted to enable chromatin binding activity. Predicted to be involved in chromatin remodeling; nervous system development; and regulation of transcription by RNA polymerase II. Predicted to be part of NuA4 histone acetyltransferase complex and SWI/SNF complex. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 76. Orthologous to human ACTL6B (actin like 6B). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See actl6b in Genome Data Viewer
    Location:
    chromosome: 23
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (44472408..44494557, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (44655894..44678037, complement)

    Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene centrobin, centrosomal BRCA2 interacting protein Neighboring gene si:ch1073-228j22.2 Neighboring gene si:ch73-375g18.1 Neighboring gene platelet glycoprotein Ib alpha chain

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC110167

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of NuA4 histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of SWI/SNF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    actin-like protein 6B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001020740.2 → NP_001018576.1  actin-like protein 6B

      See identical proteins and their annotated locations for NP_001018576.1

      Status: PROVISIONAL

      Source sequence(s)
      BC095192
      UniProtKB/TrEMBL
      Q503T4
      Related
      ENSDARP00000103569.4, ENSDART00000114640.4
      Conserved Domains (2) summary
      pfam00022
      Location:11 → 376
      Actin; Actin
      cl17037
      Location:10 → 375
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007134.7 Reference GRCz11 Primary Assembly

      Range
      44472408..44494557 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005170576.5 → XP_005170633.1  actin-like protein 6B isoform X1

      UniProtKB/TrEMBL
      A0A8M2BHY8, F8W3Z2
      Related
      ENSDARP00000124307.1, ENSDART00000148532.3
      Conserved Domains (2) summary
      pfam00022
      Location:11 → 426
      Actin; Actin
      cl17037
      Location:10 → 425
      NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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