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    pole4 polymerase (DNA-directed), epsilon 4, accessory subunit [ Danio rerio (zebrafish) ]

    Gene ID: 553610, updated on 17-Aug-2024

    Summary

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    Official Symbol
    pole4provided by ZNC
    Official Full Name
    polymerase (DNA-directed), epsilon 4, accessory subunitprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050522-309
    See related
    Ensembl:ENSDARG00000013016 AllianceGenome:ZFIN:ZDB-GENE-050522-309
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:110337
    Summary
    Predicted to enable protein heterodimerization activity. Predicted to be part of epsilon DNA polymerase complex. Predicted to be active in nucleus. Orthologous to human POLE4 (DNA polymerase epsilon 4, accessory subunit). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 11
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 11 NC_007122.7 (6197275..6206637, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 11 NC_007122.6 (6200022..6209410, complement)

    Chromosome 11 - NC_007122.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 1 member 6 Neighboring gene chemokine (C-C motif) ligand 44 Neighboring gene serine/threonine-protein kinase NIM1-like Neighboring gene chemokine (C-C motif) ligand 25b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC110337

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA-directed DNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of epsilon DNA polymerase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA polymerase epsilon subunit 4
    NP_001338727.1
    XP_017213760.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001351798.1 → NP_001338727.1  DNA polymerase epsilon subunit 4

      Status: VALIDATED

      Source sequence(s)
      EH448501, EH461577
      UniProtKB/TrEMBL
      A0A8M1P5S3
      Related
      ENSDARP00000119014.1, ENSDART00000148246.3
      Conserved Domains (1) summary
      cl28542
      Location:51 → 122
      BUR6; Class 2 transcription repressor NC2, alpha subunit (DRAP1 homolog) [Transcription]

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007122.7 Reference GRCz11 Primary Assembly

      Range
      6197275..6206637 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017358271.2 → XP_017213760.1  DNA polymerase epsilon subunit 4 isoform X1

      UniProtKB/TrEMBL
      A0A8M6Z8Q3, F1RCI6
      Related
      ENSDARP00000016362.7, ENSDART00000019440.9

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001020584.1: Suppressed sequence

      Description
      NM_001020584.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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