ca15a carbonic anhydrase XVa [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ca15aprovided by ZNC
Official Full Name: carbonic anhydrase XVaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070424-7
See related: Ensembl:ENSDARG00000015654 AllianceGenome:ZFIN:ZDB-GENE-070424-7
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:158584
Summary: Predicted to enable carbonate dehydratase activity. Acts upstream of or within regulation of pH and sodium ion import across plasma membrane. Located in external side of plasma membrane. Is expressed in several structures, including gill; hair cell; ionocyte; pleuroperitoneal region; and yolk. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: chromosome: 12

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (4320176..4335293, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (4283518..4298680, complement)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables carbonate dehydratase activity	IBA Inferred from Biological aspect of Ancestor more info
enables carbonate dehydratase activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in one-carbon metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of pH	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sodium ion import across plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sodium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: carbonic anhydrase XVa

Names: ca4c; carbonic anhydrase IV-like protein; carbonic anhydrase XV a; zCA15a

NP_001075158.1

EC 4.2.1.1

XP_017213949.1

EC 4.2.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081689.1 → NP_001075158.1 carbonic anhydrase XVa precursor

See identical proteins and their annotated locations for NP_001075158.1

Status: PROVISIONAL

Source sequence(s)

BC129308

UniProtKB/TrEMBL

A2VD39

Related

ENSDARP00000019816.8, ENSDART00000008893.10

Conserved Domains (1) summary

cd03117
Location:48 → 291

alpha_CA_IV_XV_like; Carbonic anhydrase alpha, CA_IV, CA_XV, like isozymes. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon ...