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    alkbh8 alkB homolog 8, tRNA methyltransferase [ Xenopus tropicalis (tropical clawed frog) ]

    Gene ID: 550051, updated on 17-Aug-2024

    Summary

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    Official Symbol
    alkbh8provided by Xenbase
    Official Full Name
    alkB homolog 8, tRNA methyltransferaseprovided by Xenbase
    Primary source
    Xenbase:XB-GENE-985927
    See related
    Ensembl:ENSXETG00000014487
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Xenopus tropicalis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    104 current UCB_Xtro_10.0 (GCF_000004195.4) 2 NC_030678.2 (160135591..160155326)
    103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 2 NC_030678.1 (157051170..157072439)

    Chromosome 2 - NC_030678.2Genomic Context describing neighboring genes Neighboring gene sarcolipin Neighboring gene ELMO/CED-12 domain containing 1 Neighboring gene uncharacterized LOC100492546 Neighboring gene CWF19 like cell cycle control factor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables S-adenosylmethionine-dependent methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA wobble uridine modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alkylated DNA repair protein alkB homolog 8
    Names
    S-adenosyl-L-methionine-dependent tRNA methyltransferase ABH8
    alkB, alkylation repair homolog 8
    probable alpha-ketoglutarate-dependent dioxygenase ABH8
    tRNA (carboxymethyluridine(34)-5-O)-methyltransferase ABH8
    NP_001017297.2
    XP_012812512.2
    XP_012812513.2
    XP_012812514.2
    XP_012812515.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001017297.3 → NP_001017297.2  alkylated DNA repair protein alkB homolog 8

      Status: VALIDATED

      Source sequence(s)
      CR855607, CX511363
      UniProtKB/Swiss-Prot
      Q07G10
      Related
      ENSXETP00000031718.5, ENSXETT00000031718.5
      Conserved Domains (4) summary
      COG0724
      Location:39 → 108
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12431
      Location:42 → 120
      RRM_ALKBH8; RNA recognition motif in alkylated DNA repair protein alkB homolog 8 (ALKBH8) and similar proteins
      pfam08241
      Location:411 → 500
      Methyltransf_11; Methyltransferase domain
      cl21496
      Location:137 → 332
      2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

    RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UCB_Xtro_10.0 Primary Assembly

    Genomic

    1. NC_030678.2 Reference UCB_Xtro_10.0 Primary Assembly

      Range
      160135591..160155326
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_012957059.3 → XP_012812513.2  alkylated DNA repair protein alkB homolog 8 isoform X2

      UniProtKB/Swiss-Prot
      Q07G10
      UniProtKB/TrEMBL
      A0A8J0SCU5
      Conserved Domains (3) summary
      pfam13649
      Location:416 → 503
      Methyltransf_25; Methyltransferase domain
      cd12431
      Location:49 → 127
      RRM_ALKBH8; RNA recognition motif (RRM) found in alkylated DNA repair protein alkB homolog 8 (ALKBH8) and similar proteins
      cl21496
      Location:144 → 339
      2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

    2. XM_012957058.3 → XP_012812512.2  alkylated DNA repair protein alkB homolog 8 isoform X1

      UniProtKB/Swiss-Prot
      Q07G10
      UniProtKB/TrEMBL
      A0A8J0SFV0
      Conserved Domains (3) summary
      pfam13649
      Location:419 → 506
      Methyltransf_25; Methyltransferase domain
      cd12431
      Location:52 → 130
      RRM_ALKBH8; RNA recognition motif (RRM) found in alkylated DNA repair protein alkB homolog 8 (ALKBH8) and similar proteins
      cl21496
      Location:147 → 342
      2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

    3. XM_012957061.3 → XP_012812515.2  alkylated DNA repair protein alkB homolog 8 isoform X3

      UniProtKB/Swiss-Prot
      Q07G10
      UniProtKB/TrEMBL
      A0A8J0SFR5
      Conserved Domains (3) summary
      pfam13649
      Location:409 → 496
      Methyltransf_25; Methyltransferase domain
      cd12431
      Location:42 → 120
      RRM_ALKBH8; RNA recognition motif (RRM) found in alkylated DNA repair protein alkB homolog 8 (ALKBH8) and similar proteins
      cl21496
      Location:137 → 332
      2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily

    4. XM_012957060.3 → XP_012812514.2  alkylated DNA repair protein alkB homolog 8 isoform X3

      UniProtKB/Swiss-Prot
      Q07G10
      UniProtKB/TrEMBL
      A0A8J0SFR5
      Conserved Domains (3) summary
      pfam13649
      Location:409 → 496
      Methyltransf_25; Methyltransferase domain
      cd12431
      Location:42 → 120
      RRM_ALKBH8; RNA recognition motif (RRM) found in alkylated DNA repair protein alkB homolog 8 (ALKBH8) and similar proteins
      cl21496
      Location:137 → 332
      2OG-FeII_Oxy; 2OG-Fe(II) oxygenase superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q07G10.2 GenPept UniProtKB/Swiss-Prot:Q07G10

    Gene LinkOut

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