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    aph1a aph-1 homolog A, gamma secretase subunit [ Xenopus tropicalis (tropical clawed frog) ]

    Gene ID: 548560, updated on 4-Nov-2024

    Summary

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    Official Symbol
    aph1aprovided by Xenbase
    Official Full Name
    aph-1 homolog A, gamma secretase subunitprovided by Xenbase
    Primary source
    Xenbase:XB-GENE-921428
    See related
    Ensembl:ENSXETG00000016439 AllianceGenome:Xenbase:XB-GENE-921428
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus tropicalis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
    Also known as
    aph-1a; cgi-78
    Summary
    Predicted to enable protein-macromolecule adaptor activity. Predicted to act upstream of or within Notch signaling pathway; positive regulation of catalytic activity; and protein processing. Predicted to be located in membrane. Predicted to be part of gamma-secretase complex. Orthologous to human APH1A (aph-1 homolog A, gamma-secretase subunit). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See aph1a in Genome Data Viewer
    Location:
    chromosome: 8
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    104 current UCB_Xtro_10.0 (GCF_000004195.4) 8 NC_030684.2 (133398752..133406704, complement)
    103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 8 NC_030684.1 (111973823..111981773, complement)

    Chromosome 8 - NC_030684.2Genomic Context describing neighboring genes Neighboring gene circadian associated repressor of transcription Neighboring gene carbonic anhydrase 14 Neighboring gene kirre like nephrin family adhesion molecule 1 Neighboring gene SLAM family member 5-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC97845

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables protein-macromolecule adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of gamma-secretase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    gamma-secretase subunit APH-1A
    Names
    APH1A gamma secretase subunit
    anterior pharynx defective 1 homolog A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001015843.1 → NP_001015843.1  gamma-secretase subunit APH-1A

      See identical proteins and their annotated locations for NP_001015843.1

      Status: PROVISIONAL

      Source sequence(s)
      BC090132
      UniProtKB/TrEMBL
      F7CJZ7, Q5EB22
      Conserved Domains (1) summary
      pfam06105
      Location:3 → 233
      Aph-1; Aph-1 protein

    RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UCB_Xtro_10.0 Primary Assembly

    Genomic

    1. NC_030684.2 Reference UCB_Xtro_10.0 Primary Assembly

      Range
      133398752..133406704 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_012953193.3 → XP_012808647.1  gamma-secretase subunit APH-1A isoform X1

      UniProtKB/TrEMBL
      A0A803KJM5
      Related
      ENSXETP00000035860.4, ENSXETT00000035860.5
      Conserved Domains (1) summary
      pfam06105
      Location:3 → 233
      Aph-1; Aph-1 protein
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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