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    eps8l3 EPS8-like 3 [ Xenopus tropicalis (tropical clawed frog) ]

    Gene ID: 548426, updated on 4-Nov-2024

    Summary

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    Official Symbol
    eps8l3provided by Xenbase
    Official Full Name
    EPS8-like 3provided by Xenbase
    Primary source
    Xenbase:XB-GENE-982663
    See related
    Ensembl:ENSXETG00000002019 AllianceGenome:Xenbase:XB-GENE-982663
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus tropicalis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
    Summary
    Predicted to enable kinase activity. Predicted to act upstream of or within phosphorylation. Human ortholog(s) of this gene implicated in hypotrichosis 5. Orthologous to human EPS8L3 (EPS8 signaling adaptor L3). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See eps8l3 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    104 current UCB_Xtro_10.0 (GCF_000004195.4) 2 NC_030678.2 (71790739..71829464, complement)
    103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 2 NC_030678.1 (63425745..63464359, complement)

    Chromosome 2 - NC_030678.2Genomic Context describing neighboring genes Neighboring gene guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 Neighboring gene adenosine monophosphate deaminase 2 Neighboring gene glutathione S-transferase mu 1 Neighboring gene colony stimulating factor-1 Neighboring gene adenosylhomocysteinase like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC107824

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    epidermal growth factor receptor kinase substrate 8-like protein 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001015709.1 → NP_001015709.1  epidermal growth factor receptor kinase substrate 8-like protein 3

      See identical proteins and their annotated locations for NP_001015709.1

      Status: PROVISIONAL

      Source sequence(s)
      BC089640
      UniProtKB/TrEMBL
      A0A803J2E5, Q5FW39
      Related
      ENSXETP00000101985.1, ENSXETT00000124351.1
      Conserved Domains (3) summary
      cd09540
      Location:432 → 497
      SAM_EPS8-like; SAM domain of EPS8-like subfamily
      cd11764
      Location:368 → 421
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      cl17171
      Location:2 → 110
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UCB_Xtro_10.0 Primary Assembly

    Genomic

    1. NC_030678.2 Reference UCB_Xtro_10.0 Primary Assembly

      Range
      71790739..71829464 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_012961578.3 → XP_012817032.1  epidermal growth factor receptor kinase substrate 8-like protein 3 isoform X1

      UniProtKB/TrEMBL
      A0A803J2E5, A0A8J0SKW2
      Related
      ENSXETP00000004321.5, ENSXETT00000004321.5
      Conserved Domains (3) summary
      cd09540
      Location:499 → 564
      SAM_EPS8-like; SAM domain of EPS8-like subfamily
      cd11764
      Location:435 → 488
      SH3_Eps8; Src Homology 3 domain of Epidermal growth factor receptor kinase substrate 8 and similar proteins
      pfam08416
      Location:51 → 176
      PTB; Phosphotyrosine-binding domain
    Nucleotide Protein Strain
    Heading Accession and Version

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