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    ACXE Adenylyl cyclase X E [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 53426, updated on 22-Aug-2024

    Summary

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    Official Symbol
    ACXEprovided by FlyBase
    Official Full Name
    Adenylyl cyclase X Eprovided by FlyBase
    Primary source
    FLYBASE:FBgn0040506
    Locus tag
    Dmel_CG17178
    See related
    AllianceGenome:FB:FBgn0040506
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    AC; CG17178; DACXE; Dmel\CG17178
    Summary
    Predicted to enable adenylate cyclase activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; and cAMP biosynthetic process. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Orthologous to human ADCY2 (adenylate cyclase 2) and ADCY7 (adenylate cyclase 7). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See ACXE in Genome Data Viewer
    Location:
    34A2-34A2; 2-47 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (12925611..12929823)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (12925611..12929823)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Adenylyl cyclase X B Neighboring gene Adenylyl cyclase X A Neighboring gene long non-coding RNA:CR44183 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Restricted expression of a truncated adenylyl cyclase in the cephalic furrow of Drosophila melanogaster. Cann MJ, et al. Dev Genes Evol, 2000 Jan. PMID 10603085
    2. Adenylyl cyclase encoded by AC78C participates in sugar perception in Drosophila melanogaster. Ueno K, et al. Eur J Neurosci, 2008 Nov. PMID 19046378
    3. A new family of adenylyl cyclase genes in the male germline of Drosophila melanogaster. Cann MJ, et al. Dev Genes Evol, 2000 Apr. PMID 11180822
    4. Genome-wide mapping of matrix attachment regions in Drosophila melanogaster. Pathak RU, et al. BMC Genomics, 2014 Nov 25. PMID 25424749, Free PMC Article
    5. An expanded toolkit for Drosophila gene tagging using synthesized homology donor constructs for CRISPR-mediated homologous recombination. Kanca O, et al. Elife, 2022 Jun 20. PMID 35723254, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables adenylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables adenylate cyclase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cAMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cyclic nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    adenylyl cyclase X E
    Names
    ACXE-PB
    CG17178-PB
    NP_652601.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      12925611..12929823
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_144344.3 → NP_652601.3  adenylyl cyclase X E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652601.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F3YDG3, Q9VK50
      UniProtKB/TrEMBL
      Q9NJ94
      Conserved Domains (2) summary
      pfam16214
      Location:31 → 272
      AC_N; Adenylyl cyclase N-terminal extracellular and transmembrane region
      cl11967
      Location:290 → 459
      Nucleotidyl_cyc_III; Class III nucleotidyl cyclases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5BI83 Q5BI83
    Q9NJ94 Q9NJ94
    Q9VK50.3 Q9VK50

    Gene LinkOut

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