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    CAH5 Carbonic anhydrase 5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 50102, updated on 22-Aug-2024

    Summary

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    Official Symbol
    CAH5provided by FlyBase
    Official Full Name
    Carbonic anhydrase 5provided by FlyBase
    Primary source
    FLYBASE:FBgn0040629
    Locus tag
    Dmel_CG18673
    See related
    AllianceGenome:FB:FBgn0040629
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG18673; Dmel\CG18673
    Summary
    Predicted to enable carbonate dehydratase activity. Predicted to be involved in one-carbon metabolic process. Predicted to be active in plasma membrane. Is expressed in testis. Human ortholog(s) of this gene implicated in retinitis pigmentosa. Orthologous to several human genes including CA1 (carbonic anhydrase 1); CA14 (carbonic anhydrase 14); and CA3 (carbonic anhydrase 3). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    100B9-100B9; 3-102 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (31262598..31263878)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (27088320..27089600)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Carbonic anhydrase 6 Neighboring gene Carbonic anhydrase 16 Neighboring gene pickpocket 24 Neighboring gene pH-sensitive chloride channel 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Carbonic anhydrases and anion transport in mosquito midgut pH regulation. Linser PJ, et al. J Exp Biol, 2009 Jun. PMID 19448076, Free PMC Article
    2. tBRD-1 and tBRD-2 regulate expression of genes necessary for spermatid differentiation. Theofel I, et al. Biol Open, 2017 Apr 15. PMID 28235844, Free PMC Article
    3. A mitochondrial ATP synthase subunit interacts with TOR signaling to modulate protein homeostasis and lifespan in Drosophila. Sun X, et al. Cell Rep, 2014 Sep 25. PMID 25220459, Free PMC Article
    4. tBRD-1 selectively controls gene activity in the Drosophila testis and interacts with two new members of the bromodomain and extra-terminal (BET) family. Theofel I, et al. PLoS One, 2014. PMID 25251222, Free PMC Article
    5. Quercetin ameliorates Aβ toxicity in Drosophila AD model by modulating cell cycle-related protein expression. Kong Y, et al. Oncotarget, 2016 Oct 18. PMID 27626494, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables carbonate dehydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carbonate dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in one-carbon metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    carbonic anhydrase 5
    Names
    CAH5-PC
    CG18673-PC
    NP_001097988.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      31262598..31263878
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001104518.3 → NP_001097988.2  carbonic anhydrase 5 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097988.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V9Y6
      Conserved Domains (1) summary
      smart01057
      Location:43 → 294
      Carb_anhydrase; Eukaryotic-type carbonic anhydrase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V9Y6 Q9V9Y6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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