Asb4 ankyrin repeat and SOCS box-containing 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Asb4provided by RGD
Official Full Name: ankyrin repeat and SOCS box-containing 4provided by RGD
Primary source: RGD:1563114
See related: EnsemblRapid:ENSRNOG00000009197 AllianceGenome:RGD:1563114
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Asb-4
Summary: Predicted to enable ubiquitin protein ligase activity and ubiquitin protein ligase binding activity. Predicted to be involved in positive regulation of vasculogenesis and protein autoubiquitination. Predicted to be part of Cul2-RING ubiquitin ligase complex and Cul5-RING ubiquitin ligase complex. Orthologous to human ASB4 (ankyrin repeat and SOCS box containing 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Testes (RPKM 95.6), Muscle (RPKM 66.2) and 4 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 4q21

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (34473527..34511163)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (33506992..33544630)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (30461673..30501340)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The interaction of Asb-4 with IRS4 in cell lines mediates the degradation of IRS4 and decreases insulin signaling.
Title: Ankyrin repeat and SOCS box containing protein 4 (Asb-4) colocalizes with insulin receptor substrate 4 (IRS4) in the hypothalamic neurons and mediates IRS4 degradation.
Based on its differential expression, neuroanatomical distribution and colocalisation, we hypothesise that rat Asb-4 is a gene involved in energy homeostasis.
Title: Arcuate nucleus transcriptome profiling identifies ankyrin repeat and suppressor of cytokine signalling box-containing protein 4 as a gene regulated by fasting in central nervous system feeding circuits.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

Asb4 (e-PCR), detects polymorphism
- UniSTS:506740

Asb4 (e-PCR), detects polymorphism
- UniSTS:527254

Asb4 (e-PCR), detects polymorphism
- UniSTS:502749

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vasculogenesis	ISO Inferred from Sequence Orthology more info
involved_in protein autoubiquitination	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Cul2-RING ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of Cul5-RING ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info

General protein information

Go to the top of the page Help

Preferred Names: ankyrin repeat and SOCS box protein 4

Names: ankyrin repeat and SOCS box-containing protein 4

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001024318.1 → NP_001019489.1 ankyrin repeat and SOCS box protein 4

See identical proteins and their annotated locations for NP_001019489.1

Status: PROVISIONAL

Source sequence(s)

AY577765

UniProtKB/TrEMBL

A6IDT7, F7EPG5, Q6J757

Related

ENSRNOP00000012656.4, ENSRNOT00000012657.6

Conserved Domains (3) summary

PHA02874
Location:89 → 313

PHA02874; ankyrin repeat protein; Provisional

cd03723
Location:379 → 426

SOCS_ASB4_ASB18; SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the ...

sd00045
Location:77 → 104

ANK; ANK repeat [structural motif]