Pglyrp3 peptidoglycan recognition protein 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Pglyrp3provided by RGD
Full Name: peptidoglycan recognition protein 3provided by RGD
Primary source: RGD:1593164
See related: EnsemblRapid:ENSRNOG00000045617 AllianceGenome:RGD:1593164
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pglyrp3b
Summary: Predicted to enable peptidoglycan binding activity; peptidoglycan immune receptor activity; and protein heterodimerization activity. Predicted to be involved in antimicrobial humoral immune response mediated by antimicrobial peptide; defense response to Gram-positive bacterium; and detection of bacterium. Predicted to act upstream of or within biological process involved in interaction with host; negative regulation of natural killer cell differentiation involved in immune response; and negative regulation of type II interferon production. Predicted to be located in extracellular region. Predicted to be part of protein-containing complex. Orthologous to human PGLYRP3 (peptidoglycan recognition protein 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 6.6), Spleen (RPKM 3.6) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 2q34

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (180174931..180186007)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (177479693..177490769)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (191903626..192264872)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables N-acetylmuramoyl-L-alanine amidase activity	IEA Inferred from Electronic Annotation more info
enables peptidoglycan binding	ISO Inferred from Sequence Orthology more info
enables peptidoglycan immune receptor activity	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within biological process involved in interaction with host	ISO Inferred from Sequence Orthology more info
involved_in defense response to Gram-positive bacterium	ISO Inferred from Sequence Orthology more info
involved_in detection of bacterium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of natural killer cell differentiation involved in immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in peptidoglycan catabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: peptidoglycan recognition protein 3

Names: peptidoglycan recognition protein 3b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.