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    Znhit3 zinc finger, HIT-type containing 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 497975, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Znhit3provided by RGD
    Official Full Name
    zinc finger, HIT-type containing 3provided by RGD
    Primary source
    RGD:1598226
    See related
    AllianceGenome:RGD:1598226
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Trip3
    Summary
    Predicted to be involved in box C/D snoRNP assembly; maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); and snoRNA localization. Predicted to be located in cytoplasm. Predicted to be part of pre-snoRNP complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in PEHO syndrome. Orthologous to human ZNHIT3 (zinc finger HIT-type containing 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 121.9), Heart (RPKM 116.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Znhit3 in Genome Data Viewer
    Location:
    10q26
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (70246749..70287927, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (69775885..69790471, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (72227710..72235932, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2I, pseudogene 4 Neighboring gene dehydrogenase/reductase 11 Neighboring gene gametogenetin binding protein 2 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class W Neighboring gene myosin XIX Neighboring gene U6 spliceosomal RNA Neighboring gene cytochrome c oxidase subunit 7B, pseudogene 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. ZNHIT3 is defective in PEHO syndrome, a severe encephalopathy with cerebellar granule neuron loss. Anttonen AK, et al. Brain, 2017 May 1. PMID 28335020
    2. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in box C/D snoRNP assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in snoRNA localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of pre-snoRNP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger HIT domain-containing protein 3
    Names
    thyroid hormone receptor interactor 3
    zinc finger, HIT type 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001398850.1 → NP_001385779.1  zinc finger HIT domain-containing protein 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A6HHM8
      Conserved Domains (1) summary
      pfam04438
      Location:10 → 36
      zf-HIT; HIT zinc finger

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      70246749..70287927 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039087654.2 → XP_038943582.1  zinc finger HIT domain-containing protein 3 isoform X2

      UniProtKB/TrEMBL
      A6HHN0
      Conserved Domains (1) summary
      pfam04438
      Location:10 → 36
      zf-HIT; HIT zinc finger

    2. XM_039087653.2 → XP_038943581.1  zinc finger HIT domain-containing protein 3 isoform X1

      UniProtKB/TrEMBL
      A6HHM9

    RNA

    1. XR_010055228.1 RNA Sequence

    2. XR_010055229.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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