emc2 ER membrane protein complex subunit 2 [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: emc2provided by Xenbase
Official Full Name: ER membrane protein complex subunit 2provided by Xenbase
Primary source: Xenbase:XB-GENE-484487
See related: Ensembl:ENSXETG00000003604 AllianceGenome:Xenbase:XB-GENE-484487
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as: ttc35; kiaa0103
Summary: Predicted to contribute to membrane insertase activity. Predicted to act upstream of or within protein insertion into ER membrane by stop-transfer membrane-anchor sequence and tail-anchored membrane protein insertion into ER membrane. Predicted to be located in endoplasmic reticulum membrane. Predicted to be extrinsic component of endoplasmic reticulum membrane. Predicted to be part of EMC complex. Orthologous to human EMC2 (ER membrane protein complex subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	6	NC_030682.2 (133762135..133801897)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	6	NC_030682.1 (116335904..116375937, complement)

Chromosome 6 - NC_030682.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
contributes_to membrane insertase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within protein insertion into ER membrane by stop-transfer membrane-anchor sequence	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within tail-anchored membrane protein insertion into ER membrane	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of EMC complex	IBA Inferred from Biological aspect of Ancestor more info
part_of EMC complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in extrinsic component of endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ER membrane protein complex subunit 2

Names: TPR repeat protein 35; Tetratricopeptide repeat protein 35; tetratricopeptide repeat domain 35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001011398.1 → NP_001011398.1 ER membrane protein complex subunit 2

See identical proteins and their annotated locations for NP_001011398.1

Status: PROVISIONAL

Source sequence(s)

BC088602

UniProtKB/Swiss-Prot

Q5M7J9

UniProtKB/TrEMBL

A0A6I8SPN3

Related

ENSXETP00000007770.4, ENSXETT00000007770.5

Conserved Domains (3) summary

TIGR02917
Location:72 → 294

PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein

sd00006
Location:120 → 150

TPR; TPR repeat [structural motif]

pfam14559
Location:99 → 164

TPR_19; Tetratricopeptide repeat