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    rac2 Rac family small GTPase 2 [ Xenopus tropicalis (tropical clawed frog) ]

    Gene ID: 496738, updated on 4-Nov-2024

    Summary

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    Official Symbol
    rac2provided by Xenbase
    Official Full Name
    Rac family small GTPase 2provided by Xenbase
    Primary source
    Xenbase:XB-GENE-494950
    See related
    Ensembl:ENSXETG00000004629 AllianceGenome:Xenbase:XB-GENE-494950
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus tropicalis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
    Also known as
    en-7; hspc022
    Summary
    Predicted to enable GTP binding activity and GTPase activity. Predicted to act upstream of or within small GTPase-mediated signal transduction. Human ortholog(s) of this gene implicated in immunodeficiency 73a with defective neutrophil chemotaxis and leukocytosis; immunodeficiency 73b with defective neutrophil chemotaxis and lymphopenia; and immunodeficiency 73c with defective neutrophil chemotaxis and hypogammaglobulinemia. Orthologous to human RAC2 (Rac family small GTPase 2). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See rac2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    104 current UCB_Xtro_10.0 (GCF_000004195.4) 4 NC_030680.2 (123075197..123102101)
    103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 4 NC_030680.1 (112651700..112677223)

    Chromosome 4 - NC_030680.2Genomic Context describing neighboring genes Neighboring gene extracellular leucine-rich repeat and fibronectin type III domain containing 2 Neighboring gene cytohesin 4 Neighboring gene somatostatin receptor 3 Neighboring gene interleukin 2 receptor subunit beta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ras-related C3 botulinum toxin substrate 2
    Names
    ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001011285.1 → NP_001011285.1  ras-related C3 botulinum toxin substrate 2

      See identical proteins and their annotated locations for NP_001011285.1

      Status: PROVISIONAL

      Source sequence(s)
      BC087999
      UniProtKB/TrEMBL
      A0A7D9NLT7, F6WXS4, Q5M8J2
      Related
      ENSXETP00000016252.3, ENSXETT00000016252.5
      Conserved Domains (1) summary
      cd01871
      Location:3 → 176
      Rac1_like; Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)-like consists of Rac1, Rac2 and Rac3

    RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UCB_Xtro_10.0 Primary Assembly

    Genomic

    1. NC_030680.2 Reference UCB_Xtro_10.0 Primary Assembly

      Range
      123075197..123102101
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_012961000.3 → XP_012816454.1  ras-related C3 botulinum toxin substrate 2 isoform X1

      See identical proteins and their annotated locations for XP_012816454.1

      UniProtKB/TrEMBL
      A0A7D9NLT7, F6WXS4, Q5M8J2
      Conserved Domains (1) summary
      cd01871
      Location:3 → 176
      Rac1_like; Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)-like consists of Rac1, Rac2 and Rac3
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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