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    perp p53 apoptosis effector related to pmp22 [ Danio rerio (zebrafish) ]

    Gene ID: 494479, updated on 12-Sep-2024

    Summary

    Official Symbol
    perpprovided by ZNC
    Official Full Name
    p53 apoptosis effector related to pmp22provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-050104-1
    See related
    Ensembl:ENSDARG00000063572 AllianceGenome:ZFIN:ZDB-GENE-050104-1
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    fk24g11; wu:fk24g11
    Summary
    Acts upstream of or within apoptotic process involved in blood vessel morphogenesis; regulation of apoptotic process; and response to UV. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in cell-cell junction. Is expressed in several structures, including EVL; axial chorda mesoderm; digestive system; epidermis; and nervous system. Human ortholog(s) of this gene implicated in erythrokeratodermia variabilis and mutilating palmoplantar keratoderma with periorificial keratotic plaques. Orthologous to human PERP (p53 apoptosis effector related to PMP22). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
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    Genomic context

    See perp in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (1155476..1170696)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (1025185..1040405)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene dynein axonemal assembly factor 10 Neighboring gene proteasome 20S subunit beta 1 Neighboring gene tumor necrosis factor, alpha-induced protein 3 Neighboring gene oligodendrocyte transcription factor 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Markers

    Gene Ontology Provided by ZFIN

    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cell-cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in desmosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    p53 apoptosis effector related to PMP-22
    Names
    PERP, TP53 apoptosis effector

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256207.1NP_001243136.1  p53 apoptosis effector related to PMP-22

      Status: VALIDATED

      Source sequence(s)
      BX323887, EB795440
      UniProtKB/Swiss-Prot
      A0A8M1NZE2, E9QHT9
      Related
      ENSDARP00000118851.1, ENSDART00000148356.2
      Conserved Domains (1) summary
      cl21598
      Location:36162
      PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      1155476..1170696
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)