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    Taf5 TBP-associated factor 5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 47900, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Taf5provided by FlyBase
    Official Full Name
    TBP-associated factor 5provided by FlyBase
    Primary source
    FLYBASE:FBgn0010356
    Locus tag
    Dmel_CG7704
    See related
    AllianceGenome:FB:FBgn0010356
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7704; d80; Dmel\CG7704; dmTaf5; dmTAF5; dTAF5; dTAFii80; dTAFII85; dTAF[[II]]80; p85; TAF; taf5; TAF5; Taf80; TAF80; TAF80/85; Taf85; TAFII80; TAFII85; TAF[II]80; TAF[[II]]; Taf[[II]]80; TAF[[II]]80; TAF[[II]]80/85; TAF[[II]]85; TFIID; TFIID 85
    Summary
    Contributes to RNA polymerase II general transcription initiation factor activity. Involved in transcription initiation from RNA polymerase II promoter. Located in nucleus. Part of transcription factor TFIID complex. Is expressed in male accessory gland; organism; seminal vesicle; and testis. Orthologous to human TAF5 (TATA-box binding protein associated factor 5). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Taf5 in Genome Data Viewer
    Location:
    47C5-47C5; 2-63 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10877312..10879673, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6764817..6767178, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene no child left behind Neighboring gene Peroxin 6 Neighboring gene Hydroxyacid oxidase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Transcription factor IID--not so basal after all. Verrijzer CP. Science, 2001 Sep 14. PMID 11557865
    2. Molecular cloning, expression, and characterization of the Drosophila 85-kilodalton TFIID subunit. Kokubo T, et al. Mol Cell Biol, 1993 Dec. PMID 8247000, Free PMC Article
    3. Reconstitution of TATA-binding protein-associated factor/TATA-binding protein complexes for in vitro transcription. Chen JL, et al. Methods Enzymol, 1996. PMID 8791614
    4. Drosophila octamer elements and Pdm-1 dictate the coordinated transcription of core histone genes. Lee MC, et al. J Biol Chem, 2010 Mar 19. PMID 20097756, Free PMC Article
    5. A conserved motif in goosecoid mediates groucho-dependent repression in Drosophila embryos. Jiménez G, et al. Mol Cell Biol, 1999 Mar. PMID 10022895, Free PMC Article

    See all (106) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    contributes_to RNA polymerase II general transcription initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to RNA polymerase II general transcription initiation factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in transcription initiation at RNA polymerase II promoter IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription initiation at RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in transcription initiation at RNA polymerase II promoter ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription factor TFIID complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIID complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription factor TFIID complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of transcription factor TFIID complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    TBP-associated factor 5
    Names
    CG7704-PA
    TBP associated factor 80
    TBP-associated factor
    TBP-associated factor 80
    TBP-associated factor 80kD
    Taf5-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      10877312..10879673 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_057609.6 → NP_476957.1  TBP-associated factor 5 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_476957.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P49846, Q9V5R1
      Related
      FBpp0087335
      Conserved Domains (4) summary
      cd08044
      Location:114 → 245
      TAF5_NTD2; TAF5_NTD2 is the second conserved N-terminal region of TATA Binding Protein (TBP) Associated Factor 5 (TAF5), involved in forming Transcription Factor IID (TFIID)
      COG2319
      Location:319 → 674
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:373 → 646
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:380 → 448
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49846.1 P49846

    Gene LinkOut

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