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    h2ax1 H2A.X variant histone family member 1 [ Danio rerio (zebrafish) ]

    Gene ID: 449794, updated on 2-Nov-2024

    Summary

    Official Symbol
    h2ax1provided by ZNC
    Official Full Name
    H2A.X variant histone family member 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041010-42
    See related
    Ensembl:ENSDARG00000068995 AllianceGenome:ZFIN:ZDB-GENE-041010-42
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    h2afx1; zgc:101846
    Summary
    Predicted to be a structural constituent of chromatin. Predicted to be involved in defense response to other organism; disruption of plasma membrane integrity in another organism; and heterochromatin formation. Predicted to be located in extracellular space. Predicted to be part of nucleosome. Predicted to be active in nucleus. Orthologous to several human genes including H2AC21 (H2A clustered histone 21). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
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    Genomic context

    See h2ax1 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 10 NC_007121.7 (29816687..29817590)
    105 previous assembly GRCz10 (GCF_000002035.5) 10 NC_007121.6 (29930347..29931250)

    Chromosome 10 - NC_007121.7Genomic Context describing neighboring genes Neighboring gene si:ch73-261i21.5 Neighboring gene histone 2, H2, like Neighboring gene ZPR1 zinc finger Neighboring gene cytotoxic and regulatory T cell molecule

    Genomic regions, transcripts, and products

    General gene information

    Markers

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables structural constituent of chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables structural constituent of chromatin IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in defense response to Gram-positive bacterium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in disruption of plasma membrane integrity in another organism ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in heterochromatin formation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in innate immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of nucleosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of nucleosome IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    H2A.X variant histone family member 1
    Names
    H2A histone family member X1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005967.1NP_001005967.1  H2A.X variant histone family member 1

      See identical proteins and their annotated locations for NP_001005967.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083299
      UniProtKB/TrEMBL
      A6QL59, B2GP66, Q5XJK2
      Related
      ENSDARP00000090794.3, ENSDART00000100022.5
      Conserved Domains (1) summary
      PTZ00017
      Location:1128
      PTZ00017; histone H2A; Provisional

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007121.7 Reference GRCz11 Primary Assembly

      Range
      29816687..29817590
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394791.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      21133..22036
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)