socs3 suppressor of cytokine signaling 3 [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: socs3provided by Xenbase
Official Full Name: suppressor of cytokine signaling 3provided by Xenbase
Primary source: Xenbase:XB-GENE-488199
See related: Ensembl:ENSXETG00000024632 AllianceGenome:Xenbase:XB-GENE-488199
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as: cis3; ssi3; atod4; cish3; ssi-3; socs-3; xsocs3
Summary: Predicted to act upstream of or within intracellular signal transduction; negative regulation of signal transduction; and protein ubiquitination. Human ortholog(s) of this gene implicated in obesity. Orthologous to human SOCS3 (suppressor of cytokine signaling 3). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	10	NC_030686.2 (31293195..31295891, complement)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	10	NC_030686.1 (23160942..23164691, complement)

Chromosome 10 - NC_030686.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Process	Evidence Code	Pubs
acts_upstream_of_or_within intracellular signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein ubiquitination	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: suppressor of cytokine signaling 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001005696.1 → NP_001005696.1 suppressor of cytokine signaling 3

See identical proteins and their annotated locations for NP_001005696.1

Status: PROVISIONAL

Source sequence(s)

BC075262

UniProtKB/TrEMBL

Q6DJC0

Related

ENSXETP00000053080.2, ENSXETT00000053080.4

Conserved Domains (2) summary

cd10384
Location:33 → 133

SH2_SOCS3; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins

cl02533
Location:158 → 199

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...