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    Cyp4e1 Cytochrome P450 4e1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44632, updated on 22-Aug-2024

    Summary

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    Official Symbol
    Cyp4e1provided by FlyBase
    Official Full Name
    Cytochrome P450 4e1provided by FlyBase
    Primary source
    FLYBASE:FBgn0015034
    Locus tag
    Dmel_CG2062
    See related
    AllianceGenome:FB:FBgn0015034
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    4e1; CG2062; CYP4e1; CYP4E1; Cyp4el; Dmel\CG2062; P-450; P450
    Summary
    Predicted to enable heme binding activity; iron ion binding activity; and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. Is expressed in adult head; amnioserosa; and organism. Human ortholog(s) of this gene implicated in Bietti crystalline corneoretinal dystrophy. Orthologous to human CYP4V2 (cytochrome P450 family 4 subfamily V member 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    44D1-44D1; 2-59 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8447451..8449745)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4334956..4337250)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Cytochrome P450 4ad1 Neighboring gene Cytochrome P450 4e2 Neighboring gene mir-986 stem loop Neighboring gene Maltase A1 Neighboring gene Maltase A2 Neighboring gene Maltase A3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Insect cytochromes P450: diversity, insecticide resistance and tolerance to plant toxins. Scott JG, et al. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol, 1998 Nov. PMID 9972456
    2. A novel role of Drosophila cytochrome P450-4e3 in permethrin insecticide tolerance. Terhzaz S, et al. Insect Biochem Mol Biol, 2015 Dec. PMID 26073628, Free PMC Article
    3. A new cytochrome P450 from Drosophila melanogaster, CYP4G15, expressed in the nervous system. Maïbèche-Coisne M, et al. Biochem Biophys Res Commun, 2000 Jul 14. PMID 10891384
    4. Genomic regions harboring insecticide resistance-associated Cyp genes are enriched by transposable element fragments carrying putative transcription factor binding sites in two sibling Drosophila species. Carareto CM, et al. Gene, 2014 Mar 1. PMID 24361809
    5. Cytochrome P450 gene clusters in Drosophila melanogaster. Dunkov BC, et al. Mol Gen Genet, 1996 Jun 12. PMID 8676871

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cytochrome P450 4e1
    Names
    CG2062-PA
    Cyp4e1-PA
    cytochrome P450-4e1
    NP_524771.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      8447451..8449745
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080032.3 → NP_524771.1  cytochrome P450 4e1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524771.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V4T5
      Related
      FBpp0087825
      Conserved Domains (1) summary
      pfam00067
      Location:34 → 469
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V4T5.1 Q9V4T5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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