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    crbn cereblon [ Danio rerio (zebrafish) ]

    Gene ID: 445491, updated on 28-Oct-2024

    Summary

    Official Symbol
    crbnprovided by ZNC
    Official Full Name
    cereblonprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040822-43
    See related
    Ensembl:ENSDARG00000054250 AllianceGenome:ZFIN:ZDB-GENE-040822-43
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:92404
    Summary
    Predicted to enable metal ion binding activity. Involved in fin development; limb development; and otic vesicle development. Acts upstream of with a positive effect on cell population proliferation. Acts upstream of or within embryonic pectoral fin morphogenesis and otic vesicle morphogenesis. Part of ubiquitin ligase complex. Is expressed in several structures, including cranial vasculature; nervous system; notochord; otic vesicle; and radial glial cell. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 2. Orthologous to human CRBN (cereblon). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
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    Genomic context

    See crbn in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (40456798..40466838, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (40459262..40469291, complement)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene TatD DNase domain containing 2 Neighboring gene von Hippel-Lindau tumor suppressor Neighboring gene zgc:152986 Neighboring gene FYVE, RhoGEF and PH domain containing 5b

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_positive_effect cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within embryonic pectoral fin morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in fin development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in limb development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in otic vesicle development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within otic vesicle morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of Cul4A-RING E3 ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of Cul4A-RING E3 ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    protein cereblon
    Names
    zcrbn

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003996.1NP_001003996.1  protein cereblon

      See identical proteins and their annotated locations for NP_001003996.1

      Status: PROVISIONAL

      Source sequence(s)
      BC080253
      UniProtKB/Swiss-Prot
      Q68EH9
      UniProtKB/TrEMBL
      B2GQH0
      Related
      ENSDARP00000062723.5, ENSDART00000062724.6
      Conserved Domains (3) summary
      cl19481
      Location:69177
      LON; Found in ATP-dependent protease La (LON)
      cd15777
      Location:311412
      CRBN_C_like; Thalidomide-binding C-terminal domain of cereblon (CRBN) and similar protein domains
      pfam02190
      Location:68307
      LON_substr_bdg; ATP-dependent protease La (LON) substrate-binding domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      40456798..40466838 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021476835.2XP_021332510.1  protein cereblon isoform X1

      UniProtKB/TrEMBL
      A0A8M9QFB5
      Conserved Domains (2) summary
      cd15777
      Location:326383
      CRBN_C_like; Thalidomide-binding C-terminal domain of cereblon (CRBN) and similar protein domains
      pfam02190
      Location:83322
      LON_substr_bdg; ATP-dependent protease La (LON) substrate-binding domain