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    trim24 tripartite motif containing 24 [ Danio rerio (zebrafish) ]

    Gene ID: 442869, updated on 2-Nov-2024

    Summary

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    Official Symbol
    trim24provided by ZNC
    Official Full Name
    tripartite motif containing 24provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5913
    See related
    Ensembl:ENSDARG00000103350 AllianceGenome:ZFIN:ZDB-GENE-030131-5913
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    tifa; tif1a; wu:fi24g04
    Summary
    Predicted to enable transferase activity and zinc ion binding activity. Predicted to be located in chromatin. Orthologous to human TRIM24 (tripartite motif containing 24). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See trim24 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (74141400..74205303)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (72666539..72730614)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene si:cabz01069013.4 Neighboring gene si:cabz01069012.2 Neighboring gene RAB21, member RAS oncogene family Neighboring gene protein tyrosine phosphatase receptor type R Neighboring gene protein tyrosine phosphatase receptor type b Neighboring gene zmp:0000001020

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The zebrafish moonshine gene encodes transcriptional intermediary factor 1gamma, an essential regulator of hematopoiesis. Ransom DG, et al. PLoS Biol, 2004 Aug. PMID 15314655, Free PMC Article
    2. Immune gene variation associated with chromosome-scale differences among individual zebrafish genomes. McConnell SC, et al. Sci Rep, 2023 May 13. PMID 37179373, Free PMC Article
    3. Unexpected novel relational links uncovered by extensive developmental profiling of nuclear receptor expression. Bertrand S, et al. PLoS Genet, 2007 Nov. PMID 17997606, Free PMC Article
    4. Origin and evolution of TRIM proteins: new insights from the complete TRIM repertoire of zebrafish and pufferfish. Boudinot P, et al. PLoS One, 2011. PMID 21789205, Free PMC Article
    5. A network of epigenetic regulators guides developmental haematopoiesis in vivo. Huang HT, et al. Nat Cell Biol, 2013 Dec. PMID 24240475, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transcription intermediary factor 1-alpha
    Names
    tif1 alpha
    transcriptional intermediary factor 1 alpha
    tripartite motif protein 24
    NP_001002870.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002870.2 → NP_001002870.2  transcription intermediary factor 1-alpha

      See identical proteins and their annotated locations for NP_001002870.2

      Status: PROVISIONAL

      Source sequence(s)
      BC096849
      UniProtKB/TrEMBL
      Q4V9K7
      Related
      ENSDARP00000130383.1, ENSDART00000166994.2
      Conserved Domains (7) summary
      cd05502
      Location:771 → 877
      Bromo_tif1_like; Bromodomain; tif1_like subfamily. Tif1 (transcription intermediary factor 1) is a member of the tripartite motif (TRIM) protein family, which is characterized by a particular domain architecture. It functions by recruiting coactivators and/or ...
      smart00336
      Location:132 → 176
      BBOX; B-Box-type zinc finger
      COG5034
      Location:604 → 744
      TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
      cd00021
      Location:192 → 230
      BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
      pfam14634
      Location:51 → 103
      zf-RING_5; zinc-RING finger domain
      cl22851
      Location:699 → 744
      PHD_SF; PHD finger superfamily
      cl23765
      Location:237 → 363
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      74141400..74205303
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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