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    RunxA Runt related A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 4379817, updated on 2-Nov-2024

    Summary

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    Official Symbol
    RunxAprovided by FlyBase
    Official Full Name
    Runt related Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0083981
    Locus tag
    Dmel_CG34145
    See related
    AllianceGenome:FB:FBgn0083981
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG1379; CG15453; CG34145; Dmel\CG34145; RunXA; RUNXA
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in dendrite morphogenesis. Predicted to be located in nucleus. Is expressed in circular visceral muscle fiber and visceral muscle primordium. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); female reproductive organ cancer (multiple); lung non-small cell carcinoma; pancreatic cancer; and urinary bladder cancer. Orthologous to human RUNX3 (RUNX family transcription factor 3). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See RunxA in Genome Data Viewer
    Location:
    19D3-19E1; 1-65 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (20590252..20623773, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (20461279..20494800, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Runt related B Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR45466 Neighboring gene Cytochrome P450 6v1 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The evolution of Runx genes I. A comparative study of sequences from phylogenetically diverse model organisms. Rennert J, et al. BMC Evol Biol, 2003 Mar 24. PMID 12659662, Free PMC Article
    2. Conserved cluster organization of insect Runx genes. Bao R, et al. Dev Genes Evol, 2008 Oct. PMID 18758811
    3. Evolutionary origin and genomic organisation of runt-domain containing genes in arthropods. Duncan EJ, et al. BMC Genomics, 2008 Nov 25. PMID 19032778, Free PMC Article
    4. Interactions and Feedbacks in E-Cadherin Transcriptional Regulation. Ramirez Moreno M, et al. Front Cell Dev Biol, 2021. PMID 34262912, Free PMC Article
    5. Post-transcriptional regulation of transcription factor codes in immature neurons drives neuronal diversity. Guan W, et al. Cell Rep, 2022 Jun 28. PMID 35767953, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    mobile_element

    • Loc: c20615191-20614832 mobile_element_type = transposon:INE-1{}5471

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in dendrite morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    runt related A
    Names
    CG34145-PB
    CG34145-PC
    CG34145-PD
    RunxA-PB
    RunxA-PC
    RunxA-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      20590252..20623773 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001042820.3 → NP_001036285.2  runt related A, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036285.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0KHQ3
      Conserved Domains (1) summary
      pfam00853
      Location:92 → 217
      Runt; Runt domain

    2. NM_134556.2 → NP_608400.2  runt related A, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608400.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      R9PY33
      Conserved Domains (1) summary
      pfam00853
      Location:92 → 217
      Runt; Runt domain

    3. NM_001272818.1 → NP_001259747.1  runt related A, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259747.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PI08
      Conserved Domains (1) summary
      pfam00853
      Location:95 → 216
      Runt; Runt domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PI08 M9PI08
    Q0KHQ3 Q0KHQ3
    R9PY33 R9PY33

    Gene LinkOut

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