Wdr24 WD repeat domain 24 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Wdr24provided by FlyBase
Official Full Name: WD repeat domain 24provided by FlyBase
Primary source: FLYBASE:FBgn0027518
Locus tag: Dmel_CG7609
See related: AllianceGenome:FB:FBgn0027518
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:LD21720; CG7609; Dmel\CG7609; FBtr0085543; GATOR2; Sea2; SEA2; wdr24; WDR24
Summary: Involved in several processes, including cellular response to amino acid starvation; lysosomal lumen acidification; and positive regulation of TORC1 signaling. Located in autolysosome. Part of Seh1-associated complex. Orthologous to human WDR24 (WD repeat domain 24). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 99B9-99B10; 3-99 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (29741972..29745092, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (25567694..25570814, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

we define the in vivo role of the GATOR2 component Wdr24 in Drosophila. Using a combination of genetic, biochemical, and cell biological techniques we demonstrate that Wdr24 has both TORC1 dependent and independent functions in the regulation of cellular metabolism
Title: The GATOR2 Component Wdr24 Regulates TORC1 Activity and Lysosome Function.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Process	Evidence Code	Pubs
involved_in cellular response to amino acid starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to amino acid starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lysosomal lumen acidification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of TOR signaling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of TOR signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of TORC1 signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of macroautophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of macroautophagy	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of GATOR2 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of GATOR2 complex	TAS Traceable Author Statement more info	PubMed
part_of Seh1-associated complex	IDA Inferred from Direct Assay more info	PubMed
part_of Seh1-associated complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in autolysosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in vacuolar membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: WD repeat domain 24

Names: CG7609-PB; CG7609-PC; Wdr24-PB; Wdr24-PC

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

29741972..29745092 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_143463.5 → NP_651720.3 WD repeat domain 24, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_651720.3

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9XZ25

Related

FBpp0084909

Conserved Domains (4) summary

COG2319
Location:22 → 312

WD40; WD40 repeat [General function prediction only]

cd00200
Location:13 → 311

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:70 → 109

7WD40; WD40 repeat [structural motif]

cl24077
Location:719 → 776

Zn_ribbon_17; Zinc-ribbon, C4HC2 type
NM_170424.2 → NP_733303.2 WD repeat domain 24, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_733303.2

Status: REVIEWED

UniProtKB/TrEMBL

Q86BR7

Conserved Domains (4) summary

COG2319
Location:22 → 312

WD40; WD40 repeat [General function prediction only]

cd00200
Location:13 → 311

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:70 → 109

7WD40; WD40 repeat [structural motif]

cl24077
Location:720 → 777

Zn_ribbon_17; Zinc-ribbon, C4HC2 type