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    DIP-gamma Dpr-interacting protein gamma [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43417, updated on 2-Nov-2024

    Summary

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    Official Symbol
    DIP-gammaprovided by FlyBase
    Official Full Name
    Dpr-interacting protein gammaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039617
    Locus tag
    Dmel_CG14521
    See related
    AllianceGenome:FB:FBgn0039617
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    14521; anon-WO0140519.196; CG14521; CT34248; DIPgamma; Dmel\CG14521
    Summary
    Involved in establishment of synaptic specificity at neuromuscular junction; photoreceptor cell axon guidance; and regulation of neuromuscular junction development. Located in neuron projection membrane. Is expressed in several structures, including adult head; ganglia; lobula plate tangential neurons; medulla layer; and optic lobe intrinsic neurons. Human ortholog(s) of this gene implicated in ovarian cancer. Orthologous to several human genes including IGLON5 (IgLON family member 5); NTM (neurotrimin); and OPCML (opioid binding protein/cell adhesion molecule like). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See DIP-gamma in Genome Data Viewer
    Location:
    98F2-98F4; 3-97 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (28925004..28970372, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (24750726..24796094, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Neprilysin-like 21 Neighboring gene Darkener of apricot Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45669 Neighboring gene waterproof Neighboring gene mir-4947 stem loop

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Control of Synaptic Specificity by Establishing a Relative Preference for Synaptic Partners. Xu C, et al. Neuron, 2019 Sep 4. PMID 31300277, Free PMC Article
    2. The development and function of neuronal subtypes processing color and skylight polarization in the optic lobes of Drosophila melanogaster. Sancer G, et al. Arthropod Struct Dev, 2021 Mar. PMID 33618155
    3. Molecular basis of synaptic specificity by immunoglobulin superfamily receptors in Drosophila. Cheng S, et al. Elife, 2019 Jan 28. PMID 30688651, Free PMC Article
    4. Stereotyped terminal axon branching of leg motor neurons mediated by IgSF proteins DIP-α and Dpr10. Venkatasubramanian L, et al. Elife, 2019 Feb 4. PMID 30714901, Free PMC Article
    5. Interactions between Dpr11 and DIP-γ control selection of amacrine neurons in Drosophila color vision circuits. Menon KP, et al. Elife, 2019 Nov 6. PMID 31692445, Free PMC Article

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Interactions between Dpr11 and DIP-gamma control selection of amacrine neurons in Drosophila color vision circuits.
      Title: Interactions between Dpr11 and DIP-γ control selection of amacrine neurons in Drosophila color vision circuits.
    2. study provides evidence that DIPgamma in yDm8 neurons and Dpr11 in yR7 photpreceptors instruct synaptic partner matching
      Title: Coordination between stochastic and deterministic specification in the Drosophila visual system.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in establishment of synaptic specificity at neuromuscular junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in photoreceptor cell axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of neuromuscular junction development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synapse organization IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuron projection membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Dpr-interacting protein gamma
    Names
    CG14521-PA
    DIP-gamma-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      28925004..28970372 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143392.3 → NP_651649.1  Dpr-interacting protein gamma [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651649.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VAR6
      Related
      FBpp0084716
      Conserved Domains (2) summary
      smart00410
      Location:247 → 355
      IG_like; Immunoglobulin like
      cl11960
      Location:140 → 238
      Ig; Immunoglobulin domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VAR6 Q9VAR6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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