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    Ets97D Ets at 97D [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43236, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Ets97Dprovided by FlyBase
    Official Full Name
    Ets at 97Dprovided by FlyBase
    Primary source
    FLYBASE:FBgn0004510
    Locus tag
    Dmel_CG6338
    See related
    AllianceGenome:FB:FBgn0004510
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6338; d-elg; D-elg; D-Elg; delg; Delg; DELG; Dmel\CG6338; elg; Elg; Ets; tne; tny
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in several processes, including positive regulation of oxidative phosphorylation; positive regulation of transcription by RNA polymerase II; and regulation of glutamine family amino acid metabolic process. Predicted to be active in nucleus. Is expressed in organism; posterior midgut primordium; and primordial germ cell. Orthologous to human GABPA (GA binding protein transcription factor subunit alpha). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
    all
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    Genomic context

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    See Ets97D in Genome Data Viewer
    Location:
    97D7-97D7; 3-92 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (26910775..26912886, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (22736497..22738608, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene male sterile (3) K81 Neighboring gene uncharacterized protein Neighboring gene rough Neighboring gene Transcript 48 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization and structural organization of D-elg, an ets proto-oncogene-related gene of Drosophila. The SM, et al. Oncogene, 1992 Dec. PMID 1461651
    2. Ets oncogene-related gene Elg functions in Drosophila oogenesis. Schulz RA, et al. Proc Natl Acad Sci U S A, 1993 Nov 1. PMID 8234259, Free PMC Article
    3. A cis-regulatory element promoting increased transcription at low temperature in cultured ectothermic Drosophila cells. Bai Y, et al. BMC Genomics, 2021 Oct 28. PMID 34711176, Free PMC Article
    4. D-elg, a member of the Drosophila ets gene family: sequence, expression and evolutionary comparison. Pribyl LJ, et al. Oncogene, 1991 Jul. PMID 1713660
    5. The yan gene is highly conserved in Drosophila and its expression suggests a complex role throughout development. Price MD, et al. Dev Genes Evol, 1999 Apr. PMID 10079364

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Delg and cyclin D/Cdk4 have roles in nutritional control of mitochondrial biogenesis in the Drosophila adipose tissue
      Title: Nutrition controls mitochondrial biogenesis in the Drosophila adipose tissue through Delg and cyclin D/Cdk4.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to starvation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of oxidative phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of glutamine family amino acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of mitochondrion organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Ets at 97D
    Names
    CG6338-PA
    CG6338-PB
    Ets like gene
    Ets97D-PA
    Ets97D-PB
    tiny
    tiny eggs

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      26910775..26912886 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079799.3 → NP_524523.2  Ets at 97D, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524523.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q04688, Q1LZ02, Q8SZC7, Q9VBA4
      Related
      FBpp0084458
      Conserved Domains (3) summary
      cd08534
      Location:184 → 272
      SAM_PNT-GABP-alpha; Sterile alpha motif (SAM)/Pointed domain of GA-binding protein (GABP) alpha chain
      smart00413
      Location:345 → 429
      ETS; erythroblast transformation specific domain
      pfam11620
      Location:48 → 123
      GABP-alpha; GA-binding protein alpha chain

    2. NM_001276071.1 → NP_001263000.1  Ets at 97D, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001263000.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHY6
      Conserved Domains (3) summary
      cd08534
      Location:184 → 272
      SAM_PNT-GABP-alpha; Sterile alpha motif (SAM)/Pointed domain of GA-binding protein (GABP) alpha chain
      smart00413
      Location:345 → 429
      ETS; erythroblast transformation specific domain
      pfam11620
      Location:48 → 123
      GABP-alpha; GA-binding protein alpha chain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KHY6 A0A0B4KHY6
    Q04688.2 Q04688

    Gene LinkOut

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