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    CycB3 Cyclin B3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42971, updated on 27-Aug-2024

    Summary

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    Official Symbol
    CycB3provided by FlyBase
    Official Full Name
    Cyclin B3provided by FlyBase
    Primary source
    FLYBASE:FBgn0015625
    Locus tag
    Dmel_CG5814
    See related
    AllianceGenome:FB:FBgn0015625
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.414; CG5814; Cyc B3; cycB3; Dmel\CG5814; l(3)L6540
    Summary
    Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Involved in mitotic cytokinesis; regulation of chromatin binding activity; and syncytial blastoderm mitotic cell cycle. Located in nucleus. Is expressed in several structures, including ectoderm; embryonic brain; embryonic/larval nervous system; extended germ band embryo; and neuroblasts. Orthologous to human CCNB3 (cyclin B3). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    96B1-96B1; 3-86 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24867934..24870816, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20693656..20696538, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Sting-regulated gene 1 Neighboring gene Elastin-like Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cyclin B3 is a mitotic cyclin that promotes the metaphase-anaphase transition. Yuan K, et al. Curr Biol, 2015 Mar 16. PMID 25754637, Free PMC Article
    2. Whole-genome analysis of animal A- and B-type cyclins. Nieduszynski CA, et al. Genome Biol, 2002. PMID 12537559, Free PMC Article
    3. Cyclin specificity: how many wheels do you need on a unicycle? Miller ME, et al. J Cell Sci, 2001 May. PMID 11329367
    4. Regulating the onset of mitosis. Ohi R, et al. Curr Opin Cell Biol, 1999 Apr. PMID 10209160
    5. 3' non-translated sequences in Drosophila cyclin B transcripts direct posterior pole accumulation late in oogenesis and peri-nuclear association in syncytial embryos. Dalby B, et al. Development, 1992 Aug. PMID 1451670

    See all (121) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cyclin B3 activates the Anaphase-Promoting Complex/Cyclosome in meiosis and mitosis.
      Title: Cyclin B3 activates the Anaphase-Promoting Complex/Cyclosome in meiosis and mitosis.
    2. overexpression of cycB3 dramatically increases the cystoblast(CB) number in Drosophila ovaries, suggesting that an excess of cycB3 function delays CB differentiation. Given that the cycB3 gene is evolutionarily conserved, from insects to humans, cycB3 may also be involved in controlling the fate of germline stem cells in humans.
      Title: Cyclin B3 Deficiency Impairs Germline Stem Cell Maintenance and Its Overexpression Delays Cystoblast Differentiation in Drosophila Ovary.
    3. Changing Cyclin B3 levels showed that it accelerated progress to anaphase, even in the absence of spindle assembly checkpoint function.
      Title: Cyclin B3 is a mitotic cyclin that promotes the metaphase-anaphase transition.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitotic cell cycle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitotic cell cycle phase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic cell cycle phase transition IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cytokinesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mitotic cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cyclin-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in syncytial blastoderm mitotic cell cycle IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cyclin-dependent protein kinase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cyclin B3
    Names
    CG5814-PA
    CG5814-PB
    CycB3-PA
    CycB3-PB
    CyclinB3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      24867934..24870816 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001276005.1 → NP_001262934.1  cyclin B3, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O96718, Q9I7I0, Q9TYG8
      UniProtKB/TrEMBL
      A0A0B4KHT9
      Conserved Domains (2) summary
      pfam00134
      Location:308 → 433
      Cyclin_N; Cyclin, N-terminal domain
      pfam02984
      Location:435 → 555
      Cyclin_C; Cyclin, C-terminal domain

    2. NM_143046.3 → NP_651303.2  cyclin B3, isoform A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O96718, Q9I7I0, Q9TYG8
      UniProtKB/TrEMBL
      A0A0B4KHT9
      Related
      FBpp0084103
      Conserved Domains (2) summary
      pfam00134
      Location:308 → 433
      Cyclin_N; Cyclin, N-terminal domain
      pfam02984
      Location:435 → 555
      Cyclin_C; Cyclin, C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KHT9 A0A0B4KHT9
    Q9I7I0.1 Q9I7I0

    Gene LinkOut

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