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    slo slowpoke [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42940, updated on 18-Sep-2024

    Summary

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    Official Symbol
    sloprovided by FlyBase
    Official Full Name
    slowpokeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003429
    Locus tag
    Dmel_CG10693
    See related
    AllianceGenome:FB:FBgn0003429
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH10751; CG10693; Dmel\CG10693; dslo; dSlo; Dslo; dSlo1; fSlo; Slo; SLO; Slo1
    Summary
    Enables calcium-activated potassium channel activity. Involved in several processes, including male courtship behavior, veined wing generated song production; negative regulation of neuromuscular synaptic transmission; and regulation of synaptic assembly at neuromuscular junction. Located in membrane; neuron projection; and neuronal cell body. Is expressed in adult head; embryonic/larval midgut; embryonic/larval neuromuscular junction; and spermatozoon. Used to study alcohol use disorder; substance-related disorder; and withdrawal disorder. Human ortholog(s) of this gene implicated in Alzheimer's disease and idiopathic generalized epilepsy. Orthologous to several human genes including KCNMA1 (potassium calcium-activated channel subfamily M alpha 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See slo in Genome Data Viewer
    Location:
    96A14-96A17; 3-85 cM
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (24662491..24711595)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (20488213..20537317)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene mir-1003 stem loop Neighboring gene uncharacterized protein Neighboring gene Protoporphyrinogen oxidase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene RNA polymerase II, I and III subunit L

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Small molecule modulation of the Drosophila Slo channel elucidated by cryo-EM. Raisch T, et al. Nat Commun, 2021 Dec 9. PMID 34887422, Free PMC Article
    2. BK channels and a cGMP-dependent protein kinase (PKG) function through independent mechanisms to regulate the tolerance of synaptic transmission to acute oxidative stress at the Drosophila larval neuromuscular junction. Bollinger WL, et al. J Neurogenet, 2018 Sep. PMID 30484391
    3. Single Channel Recordings Reveal Differential β2 Subunit Modulations Between Mammalian and Drosophila BKCa(β2) Channels. Yan Z, et al. PLoS One, 2016. PMID 27755549, Free PMC Article
    4. Natural courtship song variation caused by an intronic retroelement in an ion channel gene. Ding Y, et al. Nature, 2016 Aug 18. PMID 27509856
    5. A DNA element in the slo gene modulates ethanol tolerance. Krishnan HR, et al. Alcohol, 2016 Mar. PMID 26992698, Free PMC Article

    See all (247) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Co-dependent regulation of p-BRAF and potassium channel KCNMA1 levels drives glioma progression.
      Title: Co-dependent regulation of p-BRAF and potassium channel KCNMA1 levels drives glioma progression.
    2. Small molecule modulation of the Drosophila Slo channel elucidated by cryo-EM.
      Title: Small molecule modulation of the Drosophila Slo channel elucidated by cryo-EM.
    3. we discovered that activation of PKG in BK channel loss-of-function (Slo(4)) mutants significantly decreases time to stimulus-induced synaptic failure, providing the first evidence of PKG and BK channels functioning independently to control synaptic transmission tolerance to acute oxidative stress.
      Title: BK channels and a cGMP-dependent protein kinase (PKG) function through independent mechanisms to regulate the tolerance of synaptic transmission to acute oxidative stress at the Drosophila larval neuromuscular junction.
    4. Removal of element 6b from the endogenous slo gene affected the production of functional ethanol tolerance in an ethanol-vapor recovery from sedation assay.
      Title: A DNA element in the slo gene modulates ethanol tolerance.
    5. slowpoke channels are required specifically in motoneurones for maximum firing rates during locomotion.
      Title: Transient BK outward current enhances motoneurone firing rates during Drosophila larval locomotion.
    6. SLO2 Channels Are Inhibited by All Divalent Cations That Activate SLO1 K+ Channels
      Title: SLO2 Channels Are Inhibited by All Divalent Cations That Activate SLO1 K+ Channels.
    7. Slo mutant larvae exhibit alterations in synapse morphology, active zone size and neurotransmission that are similar to dysc mutants.
      Title: Regulation of synaptic development and function by the Drosophila PDZ protein Dyschronic.
    8. Results show using the Drosophila model organism, we demonstrate a central role for the BK-type Ca(2+) -activated K(+) channel gene slo in the production of alcohol withdrawal seizures
      Title: Susceptibility to ethanol withdrawal seizures is produced by BK channel gene expression.
    9. Here we examined the action of docosahexaenoic acid on the Slo1 channel without any auxiliary subunit and sought to elucidate the biophysical mechanism and the molecular determinants of the DHA sensitivity.
      Title: A point mutation in the human Slo1 channel that impairs its sensitivity to omega-3 docosahexaenoic acid.
    10. Our work identifies a Drosophila homolog of a deaf-blindness gene as a new component of the circadian output pathway,termed DYSC(dyschronic) whish expressed in major neuronal tracts and regulates expression of SLOWPOKE
      Title: dyschronic, a Drosophila homolog of a deaf-blindness gene, regulates circadian output and Slowpoke channels.
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium-activated potassium channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables calcium-activated potassium channel activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables large conductance calcium-activated potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in circadian behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male courtship behavior, veined wing generated song production IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in male courtship behavior, veined wing generated song production NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of neuromuscular synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in potassium ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in potassium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in potassium ion transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of synaptic assembly at neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuron projection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in postsynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    slowpoke
    Names
    CG10693-PA
    CG10693-PB
    CG10693-PC
    CG10693-PD
    CG10693-PE
    CG10693-PF
    CG10693-PH
    CG10693-PI
    CG10693-PJ
    CG10693-PK
    CG10693-PL
    CG10693-PM
    CG10693-PN
    CG10693-PO
    CG10693-PP
    CG10693-PQ
    CG10693-PR
    CG10693-PS
    CG10693-PT
    CG10693-PU
    CG10693-PV
    CG10693-PW
    CG10693-PX
    slo-PA
    slo-PB
    slo-PC
    slo-PD
    slo-PE
    slo-PF
    slo-PH
    slo-PI
    slo-PJ
    slo-PK
    slo-PL
    slo-PM
    slo-PN
    slo-PO
    slo-PP
    slo-PQ
    slo-PR
    slo-PS
    slo-PT
    slo-PU
    slo-PV
    slo-PW
    slo-PX

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      24662491..24711595
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001170241.3 → NP_001163712.1  slowpoke, isoform S [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JIV7
      Conserved Domains (2) summary
      pfam00520
      Location:110 → 321
      Ion_trans; Ion transport protein
      pfam03493
      Location:470 → 566
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit

    2. NM_001275995.1 → NP_001262924.1  slowpoke, isoform T [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHT2
      Conserved Domains (2) summary
      pfam00520
      Location:110 → 321
      Ion_trans; Ion transport protein
      pfam03493
      Location:470 → 566
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit

    3. NM_001014661.4 → NP_001014661.2  slowpoke, isoform R [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q03720
      Conserved Domains (2) summary
      pfam00520
      Location:110 → 323
      Ion_trans; Ion transport protein
      pfam03493
      Location:470 → 566
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit

    4. NM_170164.4 → NP_733029.1  slowpoke, isoform B [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q03720
      Related
      FBpp0084063
      Conserved Domains (2) summary
      pfam00520
      Location:110 → 328
      Ion_trans; Ion transport protein
      pfam03493
      Location:470 → 566
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit

    5. NM_206566.4 → NP_996289.1  slowpoke, isoform C [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q03720
      Conserved Domains (2) summary
      pfam00520
      Location:110 → 328
      Ion_trans; Ion transport protein
      pfam03493
      Location:470 → 566
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit

    6. NM_001275998.1 → NP_001262927.1  slowpoke, isoform W [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHF8
      Conserved Domains (2) summary
      pfam00520
      Location:110 → 328
      Ion_trans; Ion transport protein
      pfam03493
      Location:470 → 566
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit

    7. NM_001275999.1 → NP_001262928.1  slowpoke, isoform X [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KI08
      Conserved Domains (2) summary
      pfam00520
      Location:110 → 328
      Ion_trans; Ion transport protein
      pfam03493
      Location:470 → 566
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit

    8. NM_001275997.1 → NP_001262926.1  slowpoke, isoform V [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGV3
      Conserved Domains (2) summary
      pfam00520
      Location:110 → 328
      Ion_trans; Ion transport protein
      pfam03493
      Location:470 → 566
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit

    9. NM_001014662.3 → NP_001014662.1  slowpoke, isoform F [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q03720
      Conserved Domains (2) summary
      pfam00520
      Location:127 → 345
      Ion_trans; Ion transport protein
      pfam03493
      Location:487 → 583
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit

    10. NM_001014654.3 → NP_001014654.1  slowpoke, isoform N [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V3D4, Q03720, Q24369, Q24384, Q24385, Q59DU0, Q59DU1, Q59DU2, Q59DU3, Q59DU4, Q59DU5, Q59DU6, Q59DU7, Q59DU8, Q59DU9, Q59DV0, Q59DV1, Q59DV2, Q7JP74, Q7KS13, Q86NK5, Q8IMV9, Q9TWA1, Q9VC51
      Conserved Domains (2) summary
      pfam00520
      Location:127 → 345
      Ion_trans; Ion transport protein
      pfam03493
      Location:487 → 583
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit

    11. NM_001014655.3 → NP_001014655.1  slowpoke, isoform M [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q03720
      Conserved Domains (2) summary
      pfam00520
      Location:127 → 345
      Ion_trans; Ion transport protein
      pfam03493
      Location:487 → 583
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit

    12. NM_079762.4 → NP_524486.2  slowpoke, isoform A [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q03720
      Related
      FBpp0084064
      Conserved Domains (2) summary
      pfam00520
      Location:127 → 345
      Ion_trans; Ion transport protein
      pfam03493
      Location:487 → 583
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit

    13. NM_001275996.1 → NP_001262925.1  slowpoke, isoform U [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KGZ3
      Conserved Domains (3) summary
      pfam00520
      Location:158 → 345
      Ion_trans; Ion transport protein
      pfam03493
      Location:494 → 583
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:256 → 340
      Ion_trans_2; Ion channel

    14. NM_001014657.3 → NP_001014657.1  slowpoke, isoform K [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q03720
      Conserved Domains (2) summary
      pfam00520
      Location:127 → 345
      Ion_trans; Ion transport protein
      pfam03493
      Location:487 → 583
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit

    15. NM_001014656.3 → NP_001014656.1  slowpoke, isoform L [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q03720
      Conserved Domains (2) summary
      pfam00520
      Location:127 → 345
      Ion_trans; Ion transport protein
      pfam03493
      Location:487 → 583
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit

    16. NM_001014659.3 → NP_001014659.1  slowpoke, isoform I [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q03720
      Conserved Domains (2) summary
      pfam00520
      Location:127 → 345
      Ion_trans; Ion transport protein
      pfam03493
      Location:487 → 583
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit

    17. NM_001014658.3 → NP_001014658.1  slowpoke, isoform J [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q03720
      Conserved Domains (2) summary
      pfam00520
      Location:127 → 345
      Ion_trans; Ion transport protein
      pfam03493
      Location:487 → 583
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit

    18. NM_001014660.3 → NP_001014660.1  slowpoke, isoform H [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q03720
      Conserved Domains (2) summary
      pfam00520
      Location:127 → 345
      Ion_trans; Ion transport protein
      pfam03493
      Location:487 → 583
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit

    19. NM_001014653.3 → NP_001014653.1  slowpoke, isoform O [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q03720
      Conserved Domains (2) summary
      pfam00520
      Location:127 → 345
      Ion_trans; Ion transport protein
      pfam03493
      Location:487 → 583
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit

    20. NM_001014664.3 → NP_001014664.1  slowpoke, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q03720
      Conserved Domains (3) summary
      PRK10537
      Location:290 → 401
      PRK10537; voltage-gated potassium channel protein
      pfam00520
      Location:127 → 338
      Ion_trans; Ion transport protein
      pfam03493
      Location:487 → 583
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit

    21. NM_001014663.3 → NP_001014663.1  slowpoke, isoform E [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q03720
      Conserved Domains (3) summary
      PRK10537
      Location:290 → 401
      PRK10537; voltage-gated potassium channel protein
      pfam00520
      Location:127 → 340
      Ion_trans; Ion transport protein
      pfam03493
      Location:487 → 583
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit

    22. NM_001014651.3 → NP_001014651.1  slowpoke, isoform Q [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q03720
      Conserved Domains (3) summary
      PRK10537
      Location:290 → 401
      PRK10537; voltage-gated potassium channel protein
      pfam00520
      Location:127 → 340
      Ion_trans; Ion transport protein
      pfam03493
      Location:487 → 583
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit

    23. NM_001014652.3 → NP_001014652.1  slowpoke, isoform P [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q03720
      Conserved Domains (3) summary
      PRK10537
      Location:290 → 401
      PRK10537; voltage-gated potassium channel protein
      pfam00520
      Location:127 → 340
      Ion_trans; Ion transport protein
      pfam03493
      Location:487 → 583
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KGV3 A0A0B4KGV3
    A0A0B4KGZ3 A0A0B4KGZ3
    A0A0B4KHF8 A0A0B4KHF8
    A0A0B4KHT2 A0A0B4KHT2
    A0A0B4KI08 A0A0B4KI08
    E1JIV7 E1JIV7
    Q03720.3 Q03720
    Q95T95 Q95T95

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