wge winged eye [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: wgeprovided by FlyBase
Official Full Name: winged eyeprovided by FlyBase
Primary source: FLYBASE:FBgn0051151
Locus tag: Dmel_CG31151
See related: AllianceGenome:FB:FBgn0051151
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG17621; CG31151; CG4902; Dmel\CG31151; Wge
Summary: Predicted to enable chromatin binding activity. Involved in imaginal disc morphogenesis. Located in chromatin. Orthologous to several human genes including BAHCC1 (BAH domain and coiled-coil containing 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: 94C2-94C3; 3-76 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (22710883..22721150, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (18536605..18546872, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Transcriptome analysis revealed that wge represses eye identity genes independently of Su(var)3-9 and activates TD-related genes by acting together with Su(var)3-9. These findings provide new insights into diverse types of chromatin regulation at progressive steps of cell-fate conversions.
Title: winged eye Induces Transdetermination of Drosophila Imaginal Disc by Acting in Concert with a Histone Methyltransferase, Su(var)3-9.
These findings suggest that WGE is a component of specific nuclear foci called the histone locus body in Drosophila with a role in heterochromatin formation and transposon silencing.
Title: Organ identity specification factor WGE localizes to the histone locus body and regulates histone expression to ensure genomic stability in Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables chromatin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in imaginal disc morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: winged eye

Names: CG31151-PC; CG31151-PD; CG31151-PE; CG31151-PF; wge-PC; wge-PD; wge-PE; wge-PF

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

22710883..22721150 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_170038.2 → NP_732791.2 winged eye, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732791.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q3LHL9

Conserved Domains (1) summary

cd04714
Location:1461 → 1583

BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...
NM_001275918.1 → NP_001262847.1 winged eye, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001262847.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4KHX2

Conserved Domains (1) summary

cd04714
Location:1511 → 1633

BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...
NM_001043281.2 → NP_001036746.1 winged eye, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001036746.1

Status: REVIEWED

UniProtKB/Swiss-Prot

C6TPA0, Q3LHL9, Q7KS56, Q8MSX3, Q9VCV6

Conserved Domains (1) summary

cd04714
Location:1509 → 1631

BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...
NM_170037.2 → NP_732790.3 winged eye, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_732790.3

Status: REVIEWED

UniProtKB/Swiss-Prot

Q3LHL9

Conserved Domains (1) summary

cd04714
Location:1520 → 1642

BAH_BAHCC1; BAH, or Bromo Adjacent Homology domain, as present in mammalian BAHCC1 and similar proteins. BAHCC1 stands for BAH domain and coiled-coil containing 1. BAH domains are found in a variety of proteins playing roles in transcriptional silencing and the ...