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    Rpn7 Regulatory particle non-ATPase 7 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42641, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Rpn7provided by FlyBase
    Official Full Name
    Regulatory particle non-ATPase 7provided by FlyBase
    Primary source
    FLYBASE:FBgn0028688
    Locus tag
    Dmel_CG5378
    See related
    AllianceGenome:FB:FBgn0028688
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    141231_at; anon-WO0172774.103; anon-WO0172774.106; CG5378; Dmel\CG5378; p42A; rpn7; S10a
    Summary
    Involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Part of proteasome regulatory particle. Is expressed in adult head and organism. Used to study neurodegenerative disease. Orthologous to human PSMD6 (proteasome 26S subunit, non-ATPase 6). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See Rpn7 in Genome Data Viewer
    Location:
    94A15-94A15; 3-74 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22460662..22462054, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18286384..18287776, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Adaptor Protein complex 2, mu subunit Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Comparison survey of EVOO polyphenols and exploration of healthy aging-promoting properties of oleocanthal and oleacein. Nikou T, et al. Food Chem Toxicol, 2019 Mar. PMID 30677444
    2. Overexpression of Dsk2/dUbqln results in severe developmental defects and lethality in Drosophila melanogaster that can be rescued by overexpression of the p54/Rpn10/S5a proteasomal subunit. Lipinszki Z, et al. FEBS J, 2011 Dec. PMID 21973017
    3. The Drosophila RNA Helicase Belle (DDX3) Non-Autonomously Suppresses Germline Tumorigenesis Via Regulation of a Specific mRNA Set. Kotov AA, et al. Cells, 2020 Feb 26. PMID 32111103, Free PMC Article
    4. Ubiquitylation of Drosophila p54/Rpn10/S5a regulates its interaction with the UBA-UBL polyubiquitin receptors. Lipinszki Z, et al. Biochemistry, 2012 Mar 27. PMID 22364263
    5. The proteasomal subunit Rpn6 is a molecular clamp holding the core and regulatory subcomplexes together. Pathare GR, et al. Proc Natl Acad Sci U S A, 2012 Jan 3. PMID 22187461, Free PMC Article

    See all (81) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of proteasome complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome regulatory particle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of proteasome regulatory particle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proteasome regulatory particle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of proteasome regulatory particle, lid subcomplex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    regulatory particle non-ATPase 7
    Names
    CG5378-PA
    Rpn7-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      22460662..22462054 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142791.3 → NP_651048.1  regulatory particle non-ATPase 7 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651048.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V3G7
      Related
      FBpp0083687
      Conserved Domains (3) summary
      COG5187
      Location:15 → 382
      RPN7; 26S proteasome regulatory complex component, contains PCI domain [Posttranslational modification, protein turnover, chaperones]
      pfam01399
      Location:254 → 358
      PCI; PCI domain
      pfam10602
      Location:66 → 239
      RPN7; 26S proteasome subunit RPN7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9V3G7.1 Q9V3G7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
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