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    pit pitchoune [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42595, updated on 18-Sep-2024

    Summary

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    Official Symbol
    pitprovided by FlyBase
    Official Full Name
    pitchouneprovided by FlyBase
    Primary source
    FLYBASE:FBgn0266581
    Locus tag
    Dmel_CG6375
    See related
    AllianceGenome:FB:FBgn0266581
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6375; DDX18; Dmel\CG6375; DmRH15; hel93F; Hel93F; Pit; PIT
    Summary
    Predicted to enable RNA helicase activity. Predicted to be involved in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in nucleolus. Is expressed in several structures, including embryonic/larval muscle system; extended germ band embryo; germ layer; gonad; and gut section. Orthologous to human DDX18 (DEAD-box helicase 18). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See pit in Genome Data Viewer
    Location:
    94A1-94A1; 3-74 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22034298..22038925)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (17860020..17864647)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene small Cajal body-specific RNA : MeU5-G38 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Fas-associated death domain Neighboring gene held out wings Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure and function of the nucleolus. Scheer U, et al. Curr Opin Cell Biol, 1999 Jun. PMID 10395554
    2. Coordination of cell growth with cell division. Polymenis M, et al. Curr Opin Genet Dev, 1999 Feb. PMID 10072360
    3. Human c-Myc isoforms differentially regulate cell growth and apoptosis in Drosophila melanogaster. Benassayag C, et al. Mol Cell Biol, 2005 Nov. PMID 16260605, Free PMC Article
    4. Independent active and thermodynamic processes govern the nucleolus assembly in vivo. Falahati H, et al. Proc Natl Acad Sci U S A, 2017 Feb 7. PMID 28115706, Free PMC Article
    5. A Drosophila RNA helicase gene, pitchoune, is required for cell growth and proliferation and is a potential target of d-Myc. Zaffran S, et al. Development, 1998 Sep. PMID 9716523

    See all (66) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pitchoune
    Names
    CG6375-PA
    CG6375-PB
    CG6375-PC
    helicase at 93F
    pit-PA
    pit-PB
    pit-PC
    NP_001287459.1
    NP_524446.3
    NP_732694.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      22034298..22038925
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169991.2 → NP_732694.2  pitchoune, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732694.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V384, O77001, Q8SYP5, Q9VD51
      UniProtKB/TrEMBL
      A0A0B4LHF7
      Related
      FBpp0083572
      Conserved Domains (4) summary
      COG0513
      Location:186 → 677
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      cd00079
      Location:408 → 537
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd00268
      Location:187 → 394
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
      pfam13959
      Location:569 → 627
      DUF4217; Domain of unknown function (DUF4217)

    2. NM_001300530.1 → NP_001287459.1  pitchoune, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287459.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V384, O77001, Q8SYP5, Q9VD51
      UniProtKB/TrEMBL
      A0A0B4LHF7
      Conserved Domains (4) summary
      COG0513
      Location:186 → 677
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      cd00079
      Location:408 → 537
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd00268
      Location:187 → 394
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
      pfam13959
      Location:569 → 627
      DUF4217; Domain of unknown function (DUF4217)

    3. NM_079722.4 → NP_524446.3  pitchoune, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524446.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V384, O77001, Q8SYP5, Q9VD51
      UniProtKB/TrEMBL
      A0A0B4LHF7
      Related
      FBpp0083573
      Conserved Domains (4) summary
      COG0513
      Location:186 → 677
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      cd00079
      Location:408 → 537
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cd00268
      Location:187 → 394
      DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...
      pfam13959
      Location:569 → 627
      DUF4217; Domain of unknown function (DUF4217)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LHF7 A0A0B4LHF7
    Q9VD51.2 Q9VD51

    Gene LinkOut

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