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    Dhc93AB Dynein heavy chain at 93AB [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42485, updated on 27-Aug-2024

    Summary

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    Official Symbol
    Dhc93ABprovided by FlyBase
    Official Full Name
    Dynein heavy chain at 93ABprovided by FlyBase
    Primary source
    FLYBASE:FBgn0013812
    Locus tag
    Dmel_CG3723
    See related
    AllianceGenome:FB:FBgn0013812
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG3723; dhc; Dhc; DHC; Dhc 93AB; DHC4C; dhc93AB; Dmel\CG3723
    Summary
    Predicted to enable minus-end-directed microtubule motor activity. Involved in sensory perception of sound. Predicted to be part of outer dynein arm. Is expressed in Johnston organ; Johnston organ neurons; chordotonal neurons; chordotonal organ precursor cell; and spermatozoon. Used to study sensorineural hearing loss. Human ortholog(s) of this gene implicated in Kartagener syndrome; primary ciliary dyskinesia 40; primary ciliary dyskinesia 7; and spermatogenic failure 39. Orthologous to several human genes including DNAH9 (dynein axonemal heavy chain 9). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
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    Genomic context

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    See Dhc93AB in Genome Data Viewer
    Location:
    93B4-93B7; 3-70 cM
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (21024580..21042499, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16850302..16868221, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Ral interacting protein Neighboring gene pegasus Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A family of dynein genes in Drosophila melanogaster. Rasmusson K, et al. Mol Biol Cell, 1994 Jan. PMID 8186464, Free PMC Article
    2. A force balance model of early spindle pole separation in Drosophila embryos. Cytrynbaum EN, et al. Biophys J, 2003 Feb. PMID 12547760, Free PMC Article
    3. The Y chromosomal fertility factor Threads in Drosophila hydei harbors a functional gene encoding an axonemal dynein beta heavy chain protein. Kurek R, et al. Genetics, 1998 Jul. PMID 9649526, Free PMC Article
    4. In vivo dynamics of the rough deal checkpoint protein during Drosophila mitosis. Basto R, et al. Curr Biol, 2004 Jan 6. PMID 14711415
    5. ZW10 helps recruit dynactin and dynein to the kinetochore. Starr DA, et al. J Cell Biol, 1998 Aug 10. PMID 9700164, Free PMC Article

    See all (40) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dynein intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein intermediate chain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dynein light intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein light intermediate chain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables minus-end-directed microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables minus-end-directed microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables minus-end-directed microtubule motor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium movement ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cilium movement involved in cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in 9+2 motile cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in axoneme IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of dynein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of dynein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of outer dynein arm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    dynein heavy chain at 93AB
    Names
    CG3723-PB
    CG3723-PC
    Dhc93AB-PB
    Dhc93AB-PC
    dynein-related heavy chain polypeptide

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      21024580..21042499 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079700.3 → NP_524424.2  dynein heavy chain at 93AB, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524424.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VDG0
      Conserved Domains (6) summary
      pfam03028
      Location:3789 → 4476
      Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
      pfam08385
      Location:204 → 782
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:1295 → 1698
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12777
      Location:3066 → 3409
      MT; Microtubule-binding stalk of dynein motor
      pfam12781
      Location:3437 → 3649
      AAA_9; ATP-binding dynein motor region D5
      cl21455
      Location:2438 → 2710
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_001275864.1 → NP_001262793.1  dynein heavy chain at 93AB, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262793.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHJ4
      Conserved Domains (6) summary
      pfam03028
      Location:3799 → 4486
      Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
      pfam08385
      Location:204 → 782
      DHC_N1; Dynein heavy chain, N-terminal region 1
      pfam08393
      Location:1295 → 1708
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12777
      Location:3076 → 3419
      MT; Microtubule-binding stalk of dynein motor
      pfam12781
      Location:3447 → 3659
      AAA_9; ATP-binding dynein motor region D5
      cl21455
      Location:2448 → 2720
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KHJ4 A0A0B4KHJ4
    Q9VDG0 Q9VDG0
    V9GZT0 V9GZT0

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