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    myd mayday [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42303, updated on 2-Nov-2024

    Summary

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    Official Symbol
    mydprovided by FlyBase
    Official Full Name
    maydayprovided by FlyBase
    Primary source
    FLYBASE:FBgn0051475
    Locus tag
    Dmel_CG31475
    See related
    AllianceGenome:FB:FBgn0051475
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14281; CG31475; CG3768; Dmel\CG31475
    Summary
    Predicted to enable calcium ion binding activity. Involved in maintenance of synapse structure. Acts upstream of with a positive effect on retrograde trans-synaptic signaling. Is active in trans-Golgi network. Is expressed in embryonic proventriculus and embryonic proventriculus intermediate layer. Orthologous to human SDF4 (stromal cell derived factor 4). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See myd in Genome Data Viewer
    Location:
    91F11-91F11; 3-66 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (19180659..19201096)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (15006381..15026818)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46039 Neighboring gene long non-coding RNA:CR46393 Neighboring gene cryptochrome Neighboring gene vibrator

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mayday sustains trans-synaptic BMP signaling required for synaptic maintenance with age. Sidisky JM, et al. Elife, 2021 Mar 5. PMID 33667157, Free PMC Article
    2. Molecular logic of synaptic diversity between Drosophila tonic and phasic motoneurons. Jetti SK, et al. Neuron, 2023 Nov 15. PMID 37611584
    3. Genome-Wide Association Study on Male Genital Shape and Size in Drosophila melanogaster. Takahara B, et al. PLoS One, 2015. PMID 26182199, Free PMC Article
    4. NDR kinase tricornered genetically interacts with Ccm3 and metabolic enzymes in Drosophila melanogaster tracheal development. Hudson J, et al. G3 (Bethesda), 2023 Mar 9. PMID 36653023, Free PMC Article
    5. A Hopscotch-chromatin connection. Betz A, et al. Nat Genet, 2006 Sep. PMID 16941005

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mayday sustains trans-synaptic BMP signaling required for synaptic maintenance with age.
      Title: Mayday sustains trans-synaptic BMP signaling required for synaptic maintenance with age.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    mobile_element

    • Loc: 19193036-19197275 mobile_element_type = transposon:F{}1387

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in calcium-ion regulated exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maintenance of synapse structure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_positive_effect retrograde trans-synaptic signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mayday
    Names
    CG31475-PA
    CG31475-PB
    myd-PA
    myd-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      19180659..19201096
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169851.2 → NP_732406.1  mayday, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732406.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95T97, Q9VDY9
      Related
      FBpp0083149
      Conserved Domains (2) summary
      pfam13499
      Location:160 → 224
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:344 → 398
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    2. NM_001275796.1 → NP_001262725.1  mayday, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262725.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95T97, Q9VDY9
      Conserved Domains (2) summary
      pfam13499
      Location:160 → 224
      EF-hand_7; EF-hand domain pair
      cl08302
      Location:344 → 398
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VDY9 Q9VDY9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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