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    Sgsh N-sulfoglucosamine sulfohydrolase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42266, updated on 22-Aug-2024

    Summary

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    Official Symbol
    Sgshprovided by FlyBase
    Official Full Name
    N-sulfoglucosamine sulfohydrolaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038660
    Locus tag
    Dmel_CG14291
    See related
    AllianceGenome:FB:FBgn0038660
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14291; Dmel\CG14291; SGSH
    Summary
    Predicted to enable N-acetylglucosamine-6-sulfatase activity; N-sulfoglucosamine sulfohydrolase activity; and glycosaminoglycan binding activity. Predicted to be involved in glycosaminoglycan catabolic process and heparan sulfate proteoglycan catabolic process. Is expressed in several structures, including atrium; cuboidal/columnar epithelium; embryonic dorsal apodeme; extended germ band embryo; and procephalic segment. Used to study mucopolysaccharidosis type IIIA. Human ortholog(s) of this gene implicated in mucopolysaccharidosis III and mucopolysaccharidosis type IIIA. Orthologous to human SGSH (N-sulfoglucosamine sulfohydrolase). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    Location:
    91D4-91D4; 3-65 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (18911053..18912922, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (14736775..14738644, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Endophilin A Neighboring gene Xrp1 Neighboring gene Mitochondrial pyruvate carrier

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Xrp1 genetically interacts with the ALS-associated FUS orthologue caz and mediates its toxicity. Mallik M, et al. J Cell Biol, 2018 Nov 5. PMID 30209068, Free PMC Article
    2. Nuclear genomic control of naturally occurring variation in mitochondrial function in Drosophila melanogaster. Jumbo-Lucioni P, et al. BMC Genomics, 2012 Nov 22. PMID 23171078, Free PMC Article
    3. Neuronal-specific impairment of heparan sulfate degradation in Drosophila reveals pathogenic mechanisms for Mucopolysaccharidosis type IIIA. Webber DL, et al. Exp Neurol, 2018 May. PMID 29408731
    4. TDP-43 loss of function increases TFEB activity and blocks autophagosome-lysosome fusion. Xia Q, et al. EMBO J, 2016 Jan 18. PMID 26702100, Free PMC Article
    5. Integrative genomic analysis reveals novel regulatory mechanisms of eyeless during Drosophila eye development. Yeung K, et al. Nucleic Acids Res, 2018 Dec 14. PMID 30295802, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables N-sulfoglucosamine sulfohydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycosaminoglycan catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heparan sulfate proteoglycan catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    N-sulfoglucosamine sulfohydrolase
    Names
    CG14291-PA
    Sgsh-PA
    NP_650760.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      18911053..18912922 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142503.5 → NP_650760.1  N-sulfoglucosamine sulfohydrolase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650760.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VE24
      Related
      FBpp0083138
      Conserved Domains (2) summary
      COG3119
      Location:17 → 476
      AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]
      cd16027
      Location:22 → 471
      SGSH; N-sulfoglucosamine sulfohydrolase (SGSH; sulfamidase)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VE24 Q9VE24

    Gene LinkOut

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