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    side-IV sidestep IV [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41657, updated on 2-Nov-2024

    Summary

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    Official Symbol
    side-IVprovided by FlyBase
    Official Full Name
    sidestep IVprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038156
    Locus tag
    Dmel_CG14372
    See related
    AllianceGenome:FB:FBgn0038156
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    14372; BP1073; CG14372; CT34011; Dmel\CG14372
    Summary
    Enables cell adhesion receptor activity. Involved in synapse assembly. Is active in presynaptic membrane. Is expressed in adult head; hypodermal muscle cell of A1-7; and somatic muscle primordium. [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See side-IV in Genome Data Viewer
    Location:
    87E12-87E12; 3-53 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (13450590..13464184)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (9276312..9289906)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR42756 Neighboring gene long non-coding RNA:CR45679 Neighboring gene antisense RNA:CR17025 Neighboring gene antisense RNA:CR46354 Neighboring gene long non-coding RNA:CR45914 Neighboring gene mir-252 stem loop

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Brain wiring determinants uncovered by integrating connectomes and transcriptomes. Yoo J, et al. Curr Biol, 2023 Sep 25. PMID 37647901
    2. Searching for guidance cues: follow the Sidestep trail. Aberle H. Fly (Austin), 2009 Oct-Dec. PMID 19786838
    3. Drosophila adult muscle precursor cells contribute to motor axon pathfinding and proper innervation of embryonic muscles. Lavergne G, et al. Development, 2020 Feb 17. PMID 32001438
    4. Complex formation of immunoglobulin superfamily molecules Side-IV and Beat-IIb regulates synaptic specificity. Osaka J, et al. Cell Rep, 2024 Feb 27. PMID 38381608
    5. Deconstruction of the beaten Path-Sidestep interaction network provides insights into neuromuscular system development. Li H, et al. Elife, 2017 Aug 15. PMID 28829740, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables cell adhesion receptor activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in presynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sidestep IV
    Names
    CG14372-PC
    CG14372-PD
    side IV
    side-IV-PC
    side-IV-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      13450590..13464184
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001260157.1 → NP_001247086.1  sidestep IV, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001247086.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VFU7
      Conserved Domains (6) summary
      smart00408
      Location:413 → 478
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:412 → 489
      IG_like; Immunoglobulin like
      pfam00041
      Location:593 → 675
      fn3; Fibronectin type III domain
      pfam07686
      Location:79 → 188
      V-set; Immunoglobulin V-set domain
      pfam13927
      Location:509 → 572
      Ig_3; Immunoglobulin domain
      cl11960
      Location:319 → 392
      Ig; Immunoglobulin domain

    2. NM_001038963.3 → NP_001034052.2  sidestep IV, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001034052.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VFU7
      Conserved Domains (6) summary
      smart00408
      Location:413 → 478
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:412 → 489
      IG_like; Immunoglobulin like
      pfam00041
      Location:593 → 675
      fn3; Fibronectin type III domain
      pfam07686
      Location:79 → 188
      V-set; Immunoglobulin V-set domain
      pfam13927
      Location:509 → 572
      Ig_3; Immunoglobulin domain
      cl11960
      Location:319 → 392
      Ig; Immunoglobulin domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VFU7 Q9VFU7

    Gene LinkOut

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