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    sirt6 sirtuin 6 [ Danio rerio (zebrafish) ]

    Gene ID: 415161, updated on 19-Jun-2024

    Summary

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    Official Symbol
    sirt6provided by ZNC
    Official Full Name
    sirtuin 6provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-031007-2
    See related
    Ensembl:ENSDARG00000102963 AllianceGenome:ZFIN:ZDB-GENE-031007-2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:86729
    Summary
    Predicted to enable NAD+ binding activity and transferase activity. Is expressed in liver and retina. Orthologous to human SIRT6 (sirtuin 6). [provided by Alliance of Genome Resources, Apr 2022]
    Annotation information
    Annotation category: suggests misassembly
    Orthologs
    human mouse all
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    Genomic context

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    See sirt6 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (53065029..53205293, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (53469010..53532932, complement)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene relaxin family peptide receptor 3.2a Neighboring gene uncharacterized LOC101882661 Neighboring gene elongation factor 1-delta-like Neighboring gene uncharacterized LOC100034602 Neighboring gene zgc:165603 Neighboring gene cugbp, Elav-like family member 5b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Molecular and functional characterization of sirt4 and sirt6 in Megalobrama amblycephala under high glucose metabolism. Lin ST, et al. Comp Biochem Physiol B Biochem Mol Biol, 2019 May. PMID 30772485
    2. Effect of Resveratrol on Sirtuins, OPA1, and Fis1 Expression in Adult Zebrafish Retina. Sheng W, et al. Invest Ophthalmol Vis Sci, 2018 Sep 4. PMID 30208422
    3. Propionate induces intestinal oxidative stress via Sod2 propionylation in zebrafish. Ding Q, et al. iScience, 2021 Jun 25. PMID 34142031, Free PMC Article
    4. Zebrafish Dnd protein binds to 3'UTR of geminin mRNA and regulates its expression. Chen S, et al. BMB Rep, 2010 Jun. PMID 20587335
    5. celsr1a is essential for tissue homeostasis and onset of aging phenotypes in the zebrafish. Li C, et al. Elife, 2020 Jan 27. PMID 31985398, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables NAD+ binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD+-protein-arginine ADP-ribosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD-dependent protein lysine deacetylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    NAD-dependent protein deacetylase sirtuin-6
    NP_001002071.1
    XP_021335348.1
    XP_021335349.1
    XP_021335352.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002071.1 → NP_001002071.1  NAD-dependent protein deacetylase sirtuin-6

      See identical proteins and their annotated locations for NP_001002071.1

      Status: PROVISIONAL

      Source sequence(s)
      BC071405
      UniProtKB/TrEMBL
      Q6IQK0
      Related
      ENSDARP00000134988.2, ENSDART00000163115.2
      Conserved Domains (1) summary
      cd01410
      Location:46 → 257
      SIRT7; SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent ...

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      53065029..53205293 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021479674.1 → XP_021335349.1  NAD-dependent protein deacetylase sirtuin-6 isoform X2

      UniProtKB/TrEMBL
      A0A8M9QD86
      Conserved Domains (1) summary
      cd01410
      Location:2 → 211
      SIRT7; Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein ...

    2. XM_021479677.1 → XP_021335352.1  NAD-dependent protein deacetylase sirtuin-6 isoform X3

      UniProtKB/TrEMBL
      A0A8M9PV38
      Conserved Domains (1) summary
      cl00195
      Location:1 → 185
      SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...

    3. XM_021479673.1 → XP_021335348.1  NAD-dependent protein deacetylase sirtuin-6 isoform X1

      UniProtKB/TrEMBL
      A0A8M9Q7D3
      Related
      ENSDARP00000155538.1, ENSDART00000186967.1
      Conserved Domains (1) summary
      cd01410
      Location:46 → 257
      SIRT7; SIRT7: Eukaryotic and prokaryotic group (class4) which includes human sirtuin SIRT6, SIRT7, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent ...
    Nucleotide Protein Strain
    Heading Accession and Version

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