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    Rrp46 Rrp46 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41270, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Rrp46provided by FlyBase
    Official Full Name
    Rrp46provided by FlyBase
    Primary source
    FLYBASE:FBgn0037815
    Locus tag
    Dmel_CG4043
    See related
    AllianceGenome:FB:FBgn0037815
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4043; Dmel\CG4043; dRrp46; rrp46
    Summary
    Predicted to enable RNA binding activity. Involved in regulation of gene expression. Located in cytoplasm. Part of nuclear exosome (RNase complex). Orthologous to human EXOSC5 (exosome component 5). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See Rrp46 in Genome Data Viewer
    Location:
    86B4-86B4; 3-49 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (10413301..10414242)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (6239023..6239964)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene mir-318 stem loop Neighboring gene Iron regulatory protein 1B Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Cytochrome P450 12e1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dis3- and exosome subunit-responsive 3' mRNA instability elements. Kiss DL, et al. Biochem Biophys Res Commun, 2012 Jul 6. PMID 22668878, Free PMC Article
    2. Differential distribution of exosome subunits at the nuclear lamina and in cytoplasmic foci. Graham AC, et al. Mol Biol Cell, 2006 Mar. PMID 16407406, Free PMC Article
    3. Genome-wide analysis reveals distinct substrate specificities of Rrp6, Dis3, and core exosome subunits. Kiss DL, et al. RNA, 2010 Apr. PMID 20185544, Free PMC Article
    4. Drosophila melanogaster Dis3 N-terminal domains are required for ribonuclease activities, nuclear localization and exosome interactions. Mamolen M, et al. Nucleic Acids Res, 2010 Sep. PMID 20421210, Free PMC Article
    5. An efficient protein complex purification method for functional proteomics in higher eukaryotes. Forler D, et al. Nat Biotechnol, 2003 Jan. PMID 12483225

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in U4 snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear mRNA surveillance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in poly(A)-dependent snoRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of cytoplasmic exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of exosome (RNase complex) IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear exosome (RNase complex) IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear exosome (RNase complex) ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Rrp46
    Names
    CG4043-PA
    Rrp46-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      10413301..10414242
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141744.3 → NP_650001.2  Rrp46 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650001.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95TW1, Q9VGZ2
      Related
      FBpp0081725
      Conserved Domains (2) summary
      cd11372
      Location:14 → 211
      RNase_PH_RRP46; RRP46 subunit of eukaryotic exosome
      COG0689
      Location:10 → 215
      Rph; Ribonuclease PH [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95TW1 Q95TW1
    Q9VGZ2 Q9VGZ2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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