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    gfzf GST-containing FLYWCH zinc-finger protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40858, updated on 2-Nov-2024

    Summary

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    Official Symbol
    gfzfprovided by FlyBase
    Official Full Name
    GST-containing FLYWCH zinc-finger proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0250732
    Locus tag
    Dmel_CG33546
    See related
    AllianceGenome:FB:FBgn0250732
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    cg10065; CG10065; CG31329; CG31492; CG33546; dGFZF; Dmel\CG33546; Gfzf; GFZF; l(3)84Cc; Su(Kpn)
    Summary
    Enables DNA-binding transcription factor binding activity; glutathione binding activity; and glutathione transferase activity. Involved in positive regulation of transcription by RNA polymerase II. Located in cytoplasm. Is active in nucleus. Colocalizes with euchromatin. Is expressed in amnioserosa; embryonic brain; embryonic/larval midgut; larval ventral nerve cord; and organism. [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See gfzf in Genome Data Viewer
    Location:
    84C6-84C6; 3-48 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (7145880..7150968, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (2971602..2976690, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene 48 related 1 Neighboring gene antisense RNA:CR42738 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Spindle assembly abnormal 4 Neighboring gene MAGE

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An essential cell cycle regulation gene causes hybrid inviability in Drosophila. Phadnis N, et al. Science, 2015 Dec 18. PMID 26680200, Free PMC Article
    2. Identification and characterization of a novel Drosophila melanogaster glutathione S-transferase-containing FLYWCH zinc finger protein. Dai MS, et al. Gene, 2004 Nov 10. PMID 15527965
    3. Altered Localization of Hybrid Incompatibility Proteins in Drosophila. Cooper JC, et al. Mol Biol Evol, 2019 Aug 1. PMID 31038678, Free PMC Article
    4. Functionally distinct promoter classes initiate transcription via different mechanisms reflected in focused versus dispersed initiation patterns. Serebreni L, et al. EMBO J, 2023 May 15. PMID 37013908, Free PMC Article
    5. Speciation and changes in male gene expression in Drosophila. Patlar B, et al. Genome, 2021 Feb. PMID 32730707

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. localization at telomeres significantly different between D. simulans and D. melanogaster, reflecting the rapid evolution of telomeric retrotransposon copy number composition between the two species
      Title: Altered Localization of Hybrid Incompatibility Proteins in Drosophila.
    2. Gfzf functioned epistatically with the thioredoxin peroxidase Jafrac1 and the thioredoxin reductase 1 TrxR-1 to regulate mitochondrial dynamics
      Title: Glutathione S-Transferase Regulates Mitochondrial Populations in Axons through Increased Glutathione Oxidation.
    3. GFZF is the first transcriptional coactivator with intrinsic GST activity, and its identification as a transcriptional coactivator provides an explanation for its role in numerous biological processes.
      Title: GFZF, a Glutathione S-Transferase Protein Implicated in Cell Cycle Regulation and Hybrid Inviability, Is a Transcriptional Coactivator.
    4. GST-containing FLYWCH zinc-finger protein localizes to the cytoplasm of fly cells and is expressed through all stages of fly embryonic development.
      Title: Identification and characterization of a novel Drosophila melanogaster glutathione S-transferase-containing FLYWCH zinc finger protein.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables glutathione binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutathione transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables nucleic acid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with euchromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    GST-containing FLYWCH zinc-finger protein
    Names
    CG33546-PB
    CG33546-PD
    CG33546-PE
    gfzf-PB
    gfzf-PD
    gfzf-PE
    lethal (3) 84Cc
    suppressor of killer of prune
    NP_001014609.2
    NP_001014610.1
    NP_001262335.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      7145880..7150968 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001014610.2 → NP_001014610.1  GST-containing FLYWCH zinc-finger protein, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014610.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NP69, Q9VI71
      Conserved Domains (4) summary
      cd03177
      Location:900 → 1017
      GST_C_Delta_Epsilon; C-terminal, alpha helical domain of Class Delta and Epsilon Glutathione S-transferases
      COG0625
      Location:812 → 1000
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      pfam04500
      Location:597 → 663
      FLYWCH; FLYWCH zinc finger domain
      cl00388
      Location:811 → 886
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    2. NM_001014609.3 → NP_001014609.2  GST-containing FLYWCH zinc-finger protein, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014609.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NL74, Q8INS9
      Conserved Domains (3) summary
      cd03177
      Location:89 → 206
      GST_C_Delta_Epsilon; C-terminal, alpha helical domain of Class Delta and Epsilon Glutathione S-transferases
      COG0625
      Location:1 → 189
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      cl00388
      Location:1 → 75
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    3. NM_001275406.1 → NP_001262335.1  GST-containing FLYWCH zinc-finger protein, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262335.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NP69, Q9VI71
      Conserved Domains (4) summary
      cd03177
      Location:900 → 1017
      GST_C_Delta_Epsilon; C-terminal, alpha helical domain of Class Delta and Epsilon Glutathione S-transferases
      COG0625
      Location:812 → 1000
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      pfam04500
      Location:597 → 663
      FLYWCH; FLYWCH zinc finger domain
      cl00388
      Location:811 → 886
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NP69 Q6NP69
    Q8INS9 Q8INS9

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