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    ECSIT [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40732, updated on 4-Jul-2024

    Summary

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    Official Symbol
    ECSITprovided by FlyBase
    Primary source
    FLYBASE:FBgn0028436
    Locus tag
    Dmel_CG10610
    See related
    AllianceGenome:FB:FBgn0028436
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10610; dECSIT; DmECSIT; Dmel\CG10610
    Summary
    Involved in innate immune response. Predicted to be located in cytoplasm and nucleus. Predicted to be active in mitochondrion. Is expressed in several structures, including adult head; adult heart; embryonic/larval muscle system; and visceral muscle cell. Orthologous to human ECSIT (ECSIT signaling integrator). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See ECSIT in Genome Data Viewer
    Location:
    83C5-83C5; 3-47.5 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (5856585..5857914)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (1682307..1683636)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene antisense RNA:CR46133 Neighboring gene uncharacterized protein Neighboring gene dispatched Neighboring gene uncharacterized protein Neighboring gene sidestep III Neighboring gene long non-coding RNA:CR45761

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TRAF6, a molecular bridge spanning adaptive immunity, innate immunity and osteoimmunology. Wu H, et al. Bioessays, 2003 Nov. PMID 14579250
    2. A heterotrimeric death domain complex in Toll signaling. Sun H, et al. Proc Natl Acad Sci U S A, 2002 Oct 1. PMID 12351681, Free PMC Article
    3. Toll-like receptors in the induction of the innate immune response. Aderem A, et al. Nature, 2000 Aug 17. PMID 10963608
    4. ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway. Kopp E, et al. Genes Dev, 1999 Aug 15. PMID 10465784, Free PMC Article
    5. Dissecting the concordant and disparate roles of NDUFAF3 and NDUFAF4 in mitochondrial complex I biogenesis. Murari A, et al. iScience, 2021 Aug 20. PMID 34386730, Free PMC Article

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell surface receptor protein serine/threonine kinase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in innate immune response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of oxidoreductase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of protein complex stability ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    ECSIT
    Names
    CG10610-PA
    ECSIT-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      5856585..5857914
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141345.2 → NP_649602.2  ECSIT [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649602.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8SZF7, Q9U6M0, Q9VNJ6
      UniProtKB/TrEMBL
      B6IDJ7
      Related
      FBpp0078296, FBtr0078647
      Conserved Domains (3) summary
      sd00004
      Location:68 → 100
      PPR; PPR repeat [structural motif]
      pfam06239
      Location:42 → 242
      ECSIT; Evolutionarily conserved signalling intermediate in Toll pathway
      pfam14784
      Location:245 → 374
      ECIST_C; C-terminal domain of the ECSIT protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9U6M0.2 Q9U6M0

    Gene LinkOut

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