kctd10 potassium channel tetramerization domain containing 10 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: kctd10provided by ZNC
Official Full Name: potassium channel tetramerization domain containing 10provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2843
See related: Ensembl:ENSDARG00000017115 AllianceGenome:ZFIN:ZDB-GENE-040426-2843
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:63846; wu:fb30g12
Summary: Enables transcription corepressor activity. Acts upstream of or within circulatory system development; pectoral fin development; and regulation of macromolecule biosynthetic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Is expressed in several structures, including brain; fin; head; pericardial region; and pleuroperitoneal region. Orthologous to human KCTD10 (potassium channel tetramerization domain containing 10). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (19436483..19444958, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (18932683..18941130, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fj29g06.y1 (e-PCR)
- UniSTS:198995

fi75a08.x1 (e-PCR)
- UniSTS:197973

fb30g12.x1 (e-PCR)
- UniSTS:190395

fb30g12.x1 (e-PCR)
- UniSTS:190396

fj94d09.y1 (e-PCR)
- UniSTS:200398

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	IPI Inferred from Physical Interaction more info	PubMed
contributes_to ubiquitin-protein transferase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within atrioventricular canal development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within atrioventricular canal development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endocardium development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart looping	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within heart looping	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within pectoral fin development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein homooligomerization	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of hyaluronan biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sprouting angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Cul3-RING ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

Names: potassium channel tetramerisation domain containing 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213478.2 → NP_998643.1 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

Status: VALIDATED

Source sequence(s)

BX510366

UniProtKB/TrEMBL

A0A8M1PH78, Q6P7X5

Related

ENSDARP00000122490.1, ENSDART00000136259.2

Conserved Domains (2) summary

smart00225
Location:33 → 131

BTB; Broad-Complex, Tramtrack and Bric a brac

pfam02214
Location:34 → 124

BTB_2; BTB/POZ domain