znf488 zinc finger protein 488 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: znf488provided by ZNC
Official Full Name: zinc finger protein 488provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2747
See related: Ensembl:ENSDARG00000025017 AllianceGenome:ZFIN:ZDB-GENE-040426-2747
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:63680; wu:fd12b11
Summary: Predicted to enable DNA binding activity; metal ion binding activity; and methyltransferase activity. Acts upstream of or within spinal cord motor neuron cell fate specification. Predicted to be active in nucleus. Is expressed in nervous system; neural plate; and neural tube. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy 10. Orthologous to several human genes including ZNF488 (zinc finger protein 488). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (31292699..31296358, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (31162249..31165908, complement)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zebrafish prdm8a and prdm8b genes were generated by the teleost-specific whole-genome duplication event. Their distinct expression patterns reflect a subfunctionalization, by which prdm8a and prdm8b partition different functions of the ancestral gene.
Title: Genome-wide survey and developmental expression mapping of zebrafish SET domain-containing genes.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within methylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
involved_in oligodendrocyte development	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within spinal cord motor neuron cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: zinc finger protein 488

NP_998575.1

EC 2.1.1.-

XP_005156867.1

EC 2.1.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213410.1 → NP_998575.1 zinc finger protein 488

See identical proteins and their annotated locations for NP_998575.1

Status: PROVISIONAL

Source sequence(s)

BC055201

Related

ENSDARP00000036087.5, ENSDART00000030946.6

Conserved Domains (2) summary

sd00017
Location:440 → 460

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00856
Location:32 → 129

SET; SET domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007124.7 Reference GRCz11 Primary Assembly

Range

31292699..31296358 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005156810.3 → XP_005156867.1 zinc finger protein 488 isoform X1

UniProtKB/Swiss-Prot

A0A8M2B2V3, B8A5Y1, Q7SXY1

Conserved Domains (2) summary

sd00017
Location:440 → 460

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00856
Location:32 → 129

SET; SET domain