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    Sems Seminase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40315, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Semsprovided by FlyBase
    Official Full Name
    Seminaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037036
    Locus tag
    Dmel_CG10586
    See related
    AllianceGenome:FB:FBgn0037036
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10586; Dmel\CG10586; sems; SP168
    Summary
    Enables serine hydrolase activity. Involved in negative regulation of female receptivity, post-mating; sperm storage; and zymogen activation. Located in extracellular space. Is expressed in adult head and male accessory gland. [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See Sems in Genome Data Viewer
    Location:
    78A1-78A1; 3-47 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20955755..20956750, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20948855..20949850, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene fringe Neighboring gene long non-coding RNA:CR45243 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of Drosophila-based endpoints for the assessment and understanding of xenobiotic-mediated male reproductive adversities. Misra S, et al. Toxicol Sci, 2014 Sep. PMID 24973093, Free PMC Article
    2. A Drosophila protease cascade member, seminal metalloprotease-1, is activated stepwise by male factors and requires female factors for full activity. Laflamme BA, et al. Genetics, 2014 Apr. PMID 24514904, Free PMC Article
    3. Drosophila seminal sex peptide associates with rival as well as own sperm, providing SP function in polyandrous females. Misra S, et al. Elife, 2020 Jul 16. PMID 32672537, Free PMC Article
    4. Secreted Wingless-interacting molecule (Swim) promotes long-range signaling by maintaining Wingless solubility. Mulligan KA, et al. Proc Natl Acad Sci U S A, 2012 Jan 10. PMID 22203956, Free PMC Article
    5. Long-term interaction between Drosophila sperm and sex peptide is mediated by other seminal proteins that bind only transiently to sperm. Singh A, et al. Insect Biochem Mol Biol, 2018 Nov. PMID 30217614, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables serine hydrolase activity HDA PubMed 
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of female receptivity, post-mating IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    involved_in sexual reproduction HEP PubMed 
    involved_in sperm storage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in zymogen activation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular space HDA PubMed 

    General protein information

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    Preferred Names
    seminase
    Names
    CG10586-PA
    Sems-PA
    NP_649270.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      20955755..20956750 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141013.2 → NP_649270.1  seminase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649270.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C1C3F2, Q4QQ23, Q4QQ30, Q9VP95
      Related
      FBpp0077991
      Conserved Domains (2) summary
      smart00020
      Location:43 → 263
      Tryp_SPc; Trypsin-like serine protease
      cd00190
      Location:44 → 265
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VP95.1 Q9VP95

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