tlr2 toll-like receptor 2 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tlr2provided by ZNC
Official Full Name: toll-like receptor 2provided by ZNC
Primary source: ZFIN:ZDB-GENE-040219-6
See related: Ensembl:ENSDARG00000037758 AllianceGenome:ZFIN:ZDB-GENE-040219-6
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable signaling receptor activity and triacyl lipopeptide binding activity. Acts upstream of or within activation of immune response and immune response. Predicted to be located in cytoplasm and membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in brain; integument; liver; and spleen. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); dermatitis (multiple); gastrointestinal system cancer (multiple); lung disease (multiple); and rhinitis (multiple). Orthologous to human TLR2 (toll like receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (8983491..8989759)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (8299866..8304537)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The transcriptome and infection burden analyses show a function of Tlr2 as a protective factor against mycobacteria.
Title: Infection and RNA-seq analysis of a zebrafish tlr2 mutant shows a broad function of this toll-like receptor in transcriptional and metabolic control and defense to Mycobacterium marinum infection.
Differential gene expression following TLR stimulation in rag1-/- mutant zebrafish tissues and morphological descriptions of lymphocyte-like cell populations
Title: Differential gene expression following TLR stimulation in rag1-/- mutant zebrafish tissues and morphological descriptions of lymphocyte-like cell populations.
Our studies show that Pam3CSK4 and flagellin can stimulate the Tlr2 and Tlr5 signaling pathways leading to common and specific responses in the zebrafish embryo system.
Title: Common and specific downstream signaling targets controlled by Tlr2 and Tlr5 innate immune signaling in zebrafish.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info
enables triacyl lipopeptide binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within activation of immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
involved_in toll-like receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within toll-like receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: toll-like receptor 2

Names: TIR2

NP_997977.1

EC 3.2.2.6

XP_005170910.1

EC 3.2.2.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212812.1 → NP_997977.1 toll-like receptor 2 precursor

See identical proteins and their annotated locations for NP_997977.1

Status: PROVISIONAL

Source sequence(s)

AY388399

UniProtKB/TrEMBL

Q6TS42

Related

ENSDARP00000055005.2, ENSDART00000055006.3

Conserved Domains (5) summary

smart00255
Location:641 → 784

TIR; Toll - interleukin 1 - resistance

cd00116
Location:360 → 471

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00031
Location:55 → 75

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:360 → 388

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:78 → 133

LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007112.7 Reference GRCz11 Primary Assembly

Range

8983491..8989759

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005170853.4 → XP_005170910.1 toll-like receptor 2 isoform X1

UniProtKB/TrEMBL

A0A8M2BI18, F1QWS9

Related

ENSDARP00000110559.1, ENSDART00000122568.4

Conserved Domains (5) summary

smart00255
Location:671 → 814

TIR; Toll - interleukin 1 - resistance

cd00116
Location:390 → 501

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00031
Location:85 → 105

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:390 → 418

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:108 → 163

LRR_8; Leucine rich repeat