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    Msh6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39654, updated on 22-Aug-2024

    Summary

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    Official Symbol
    Msh6provided by FlyBase
    Primary source
    FLYBASE:FBgn0036486
    Locus tag
    Dmel_CG7003
    See related
    AllianceGenome:FB:FBgn0036486
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7003; Dmel\CG7003; MSH6
    Summary
    Predicted to enable ATP-dependent activity, acting on DNA and four-way junction DNA binding activity. Predicted to contribute to MutLalpha complex binding activity; oxidized purine DNA binding activity; and single thymine insertion binding activity. Involved in meiotic mismatch repair. Predicted to be part of MutSalpha complex. Human ortholog(s) of this gene implicated in Lynch syndrome; colorectal carcinoma; endometrial cancer; hereditary nonpolyposis colorectal cancer type 5; and mismatch repair cancer syndrome. Orthologous to human MSH6 (mutS homolog 6). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Msh6 in Genome Data Viewer
    Location:
    71B6-71B6; 3-42 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (15154233..15158562, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (15147333..15151662, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45397 Neighboring gene uncharacterized protein Neighboring gene Peroxin 3 Neighboring gene alpha1,3-fucosyltransferase A Neighboring gene Pre-mRNA processing factor 31 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The role of Drosophila mismatch repair in suppressing recombination between diverged sequences. Do AT, et al. Sci Rep, 2015 Nov 30. PMID 26616528, Free PMC Article
    2. Mismatch repair systems might facilitate the chromosomal recombination induced by N-nitrosodimethylamine, but not by N-nitrosodiethylamine, in Drosophila. Negishi T, et al. Mutagenesis, 2020 Mar 27. PMID 32109288
    3. Meiotic recombination in Drosophila Msh6 mutants yields discontinuous gene conversion tracts. Radford SJ, et al. Genetics, 2007 May. PMID 17339220, Free PMC Article
    4. Eliminating both canonical and short-patch mismatch repair in Drosophila melanogaster suggests a new meiotic recombination model. Crown KN, et al. PLoS Genet, 2014 Sep. PMID 25188408, Free PMC Article
    5. DNA mismatch repair and mutation avoidance pathways. Marti TM, et al. J Cell Physiol, 2002 Apr. PMID 11920679

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ATP-dependent DNA damage sensor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mismatched DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mismatched DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in meiotic mismatch repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mismatch repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mismatch repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of MutSalpha complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Msh6
    Names
    CG7003-PA
    Msh6-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      15154233..15158562 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140498.2 → NP_648755.1  Msh6 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648755.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B6IDV3, Q9VUM0
      Related
      FBpp0075399
      Conserved Domains (7) summary
      cd03286
      Location:924 → 1140
      ABC_MSH6_euk; ATP-binding cassette domain of eukaryotic MutS6 homolog
      COG0249
      Location:261 → 1186
      MutS; DNA mismatch repair ATPase MutS [Replication, recombination and repair]
      pfam01624
      Location:263 → 375
      MutS_I; MutS domain I
      pfam05188
      Location:391 → 508
      MutS_II; MutS domain II
      pfam05190
      Location:767 → 859
      MutS_IV; MutS family domain IV
      pfam05192
      Location:584 → 667
      MutS_III; MutS domain III
      cl00788
      Location:44 → 156
      MttA_Hcf106; mttA/Hcf106 family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VUM0.2 Q9VUM0

    Gene LinkOut

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