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    eif2d eukaryotic translation initiation factor 2D [ Xenopus tropicalis (tropical clawed frog) ]

    Gene ID: 395035, updated on 17-Aug-2024

    Summary

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    Official Symbol
    eif2dprovided by Xenbase
    Official Full Name
    eukaryotic translation initiation factor 2Dprovided by Xenbase
    Primary source
    Xenbase:XB-GENE-947279
    See related
    Ensembl:ENSXETG00000023678
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus tropicalis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
    Also known as
    lgtn
    Annotation information
    Note: The name of this locus was changed from ligatin to eukaryotic translation initiation factor 2D based on the gene characterization of the human ortholog reported in PMID:20566627. [18 Aug 2011]
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 2
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    104 current UCB_Xtro_10.0 (GCF_000004195.4) 2 NC_030678.2 (74028805..74052651, complement)
    103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 2 NC_030678.1 (65660574..65684536, complement)

    Chromosome 2 - NC_030678.2Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC116408840 Neighboring gene inhibitor of nuclear factor kappa B kinase subunit epsilon Neighboring gene Ras association domain family member 5 Neighboring gene dual specificity tyrosine-(Y)-phosphorylation regulated kinase 3 Neighboring gene MAPK activated protein kinase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC76058

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation initiation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within formation of translation preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 2D
    Names
    ligatin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_204067.1 → NP_989398.1  eukaryotic translation initiation factor 2D

      See identical proteins and their annotated locations for NP_989398.1

      Status: PROVISIONAL

      Source sequence(s)
      BC064862
      UniProtKB/TrEMBL
      F7CJY3, Q6P1U9
      Related
      ENSXETP00000051096.5, ENSXETT00000051096.5
      Conserved Domains (3) summary
      cd11608
      Location:495 → 579
      eIF2D_C; C-terminal domain of eIF2D and related proteins
      COG2016
      Location:7 → 177
      Tma20; Predicted ribosome-associated RNA-binding protein Tma20, contains PUA domain [Translation, ribosomal structure and biogenesis]
      pfam17832
      Location:2 → 90
      Pre-PUA; Pre-PUA-like domain

    RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UCB_Xtro_10.0 Primary Assembly

    Genomic

    1. NC_030678.2 Reference UCB_Xtro_10.0 Primary Assembly

      Range
      74028805..74052651 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_012958652.3 → XP_012814106.1  eukaryotic translation initiation factor 2D isoform X2

      UniProtKB/TrEMBL
      A0A6I8QLT9, A0A8J0SEZ2
      Conserved Domains (2) summary
      cd11608
      Location:454 → 538
      eIF2D_C; C-terminal domain of eIF2D and related proteins
      COG2016
      Location:5 → 136
      Tma20; Predicted ribosome-associated RNA-binding protein Tma20, contains PUA domain [Translation, ribosomal structure and biogenesis]

    2. XM_012958645.3 → XP_012814099.1  eukaryotic translation initiation factor 2D isoform X1

      UniProtKB/TrEMBL
      A0A8J0SEY7, F7CJY3
      Related
      ENSXETP00000070292.2, ENSXETT00000067215.2
      Conserved Domains (4) summary
      cd11608
      Location:494 → 578
      eIF2D_C; C-terminal domain of eIF2D and related proteins
      cd11610
      Location:6 → 81
      eIF2D_N; N-terminal domain of eIF2D and related proteins
      COG2016
      Location:7 → 177
      Tma20; Predicted ribosome-associated RNA-binding protein Tma20, contains PUA domain [Translation, ribosomal structure and biogenesis]
      cl00607
      Location:64 → 174
      PUA; PUA domain
    Nucleotide Protein Strain
    Heading Accession and Version

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