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    dhcr7 7-dehydrocholesterol reductase [ Xenopus tropicalis (tropical clawed frog) ]

    Gene ID: 394844, updated on 4-Nov-2024

    Summary

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    Official Symbol
    dhcr7provided by Xenbase
    Official Full Name
    7-dehydrocholesterol reductaseprovided by Xenbase
    Primary source
    Xenbase:XB-GENE-920362
    See related
    Ensembl:ENSXETG00000008945 AllianceGenome:Xenbase:XB-GENE-920362
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus tropicalis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
    Also known as
    slos; 7-Dhcr; Xdhcr7
    Summary
    Predicted to enable 7-dehydrocholesterol reductase activity and NADP binding activity. Predicted to be involved in cholesterol biosynthetic process. Predicted to act upstream of or within sterol biosynthetic process. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in Behcet's disease and Smith-Lemli-Opitz syndrome. Orthologous to human DHCR7 (7-dehydrocholesterol reductase). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See dhcr7 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    104 current UCB_Xtro_10.0 (GCF_000004195.4) 4 NC_030680.2 (5247072..5257834)
    103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) Unplaced Scaffold NW_016683485.1 (692..3142, complement)

    Chromosome 4 - NC_030680.2Genomic Context describing neighboring genes Neighboring gene neural EGFL like 1 Neighboring gene PNMA family member 6F Neighboring gene small VCP/p97-interacting protein Neighboring gene growth arrest specific 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Clone Names

    • MGC75866

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables 7-dehydrocholesterol reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 7-dehydrocholesterol reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cholesterol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cholesterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within organic hydroxy compound biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within steroid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within sterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    7-dehydrocholesterol reductase
    Names
    7-DHC reductase
    sterol Delta(7)-reductase
    NP_989235.1
    XP_031755821.1
    XP_031755822.1
    XP_031755823.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_203904.1 → NP_989235.1  7-dehydrocholesterol reductase

      See identical proteins and their annotated locations for NP_989235.1

      Status: PROVISIONAL

      Source sequence(s)
      BC063347
      UniProtKB/Swiss-Prot
      Q6P4M0
      UniProtKB/TrEMBL
      A0A8J1JD60
      Related
      ENSXETP00000116846.1, ENSXETT00000113570.1
      Conserved Domains (1) summary
      cl21511
      Location:97 → 473
      PEMT; Phospholipid methyltransferase

    RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UCB_Xtro_10.0 Primary Assembly

    Genomic

    1. NC_030680.2 Reference UCB_Xtro_10.0 Primary Assembly

      Range
      5247072..5257834
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_031899961.1 → XP_031755821.1  7-dehydrocholesterol reductase isoform X1

      UniProtKB/TrEMBL
      A0A803JK05
      Related
      ENSXETP00000108285.1, ENSXETT00000119876.1
      Conserved Domains (1) summary
      cl21511
      Location:111 → 487
      PEMT; Phospholipid methyltransferase

    2. XM_031899962.1 → XP_031755822.1  7-dehydrocholesterol reductase isoform X2

      UniProtKB/TrEMBL
      A0A8J1JD58
      Conserved Domains (1) summary
      cl21511
      Location:110 → 486
      PEMT; Phospholipid methyltransferase

    3. XM_031899963.1 → XP_031755823.1  7-dehydrocholesterol reductase isoform X3

      UniProtKB/Swiss-Prot
      Q6P4M0
      UniProtKB/TrEMBL
      A0A8J1JD60
      Conserved Domains (1) summary
      cl21511
      Location:97 → 473
      PEMT; Phospholipid methyltransferase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P4M0.1 GenPept UniProtKB/Swiss-Prot:Q6P4M0

    Gene LinkOut

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