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    nebu nebulosa [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39458, updated on 2-Nov-2024

    Summary

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    Official Symbol
    nebuprovided by FlyBase
    Official Full Name
    nebulosaprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036316
    Locus tag
    Dmel_CG10960
    See related
    AllianceGenome:FB:FBgn0036316
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10960; CT30701; Dmel\CG10960; GLUT8
    Summary
    Enables D-glucose transmembrane transporter activity. Involved in D-glucose transmembrane transport. Located in plasma membrane. Is expressed in several structures, including adult head; adult heart; amnioserosa; ganglia; and larval glial cell. Orthologous to human SLC2A8 (solute carrier family 2 member 8). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See nebu in Genome Data Viewer
    Location:
    69E5-69E6; 3-39 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (12824880..12843106, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (12817980..12836206, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Sin3A-associated protein 130 Neighboring gene uncharacterized protein Neighboring gene Splicing factor 3a subunit 2 Neighboring gene uncharacterized protein Neighboring gene WW domain binding protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome-wide RNAi screen for host factors required for intracellular bacterial infection. Agaisse H, et al. Science, 2005 Aug 19. PMID 16020693
    2. Bowman-Birk inhibitor affects pathways associated with energy metabolism in Drosophila melanogaster. Li HM, et al. Insect Mol Biol, 2010 Jun 1. PMID 20113373
    3. Glycolysis-derived alanine from glia fuels neuronal mitochondria for memory in Drosophila. Rabah Y, et al. Nat Metab, 2023 Nov. PMID 37932430, Free PMC Article
    4. Identification of New Regulators of the Oocyte-to-Embryo Transition in Drosophila. Avilés-Pagán EE, et al. G3 (Bethesda), 2020 Sep 2. PMID 32690584, Free PMC Article
    5. Highly rearranged chromosomes reveal uncoupling between genome topology and gene expression. Ghavi-Helm Y, et al. Nat Genet, 2019 Aug. PMID 31308546, Free PMC Article

    See all (60) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables D-glucose transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables D-glucose transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables dehydroascorbic acid transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables fructose transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables sugar transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in D-glucose transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in D-glucose transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in carbohydrate transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dehydroascorbic acid transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in fructose transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane HDA PubMed 
    is_active_in plasma membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    nebulosa
    Names
    CG10960-PA
    CG10960-PB
    CG10960-PC
    nebu-PA
    nebu-PB
    nebu-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      12824880..12843106 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168523.2 → NP_729843.1  nebulosa, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729843.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IQH6
      Related
      FBpp0075673
      Conserved Domains (2) summary
      cd06174
      Location:50 → 440
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:49 → 406
      MFS_1; Major Facilitator Superfamily

    2. NM_140348.2 → NP_648605.1  nebulosa, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648605.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VU17
      Related
      FBpp0075674
      Conserved Domains (2) summary
      cd06174
      Location:118 → 508
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:117 → 474
      MFS_1; Major Facilitator Superfamily

    3. NM_168522.2 → NP_729842.1  nebulosa, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729842.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IQH6
      Related
      FBpp0075675
      Conserved Domains (2) summary
      cd06174
      Location:50 → 440
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:49 → 406
      MFS_1; Major Facilitator Superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IQH6 Q8IQH6
    Q9VU17 Q9VU17

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