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    zdhhc16a zinc finger DHHC-type palmitoyltransferase 16a [ Danio rerio (zebrafish) ]

    Gene ID: 394017, updated on 2-Nov-2024

    Summary

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    Official Symbol
    zdhhc16aprovided by ZNC
    Official Full Name
    zinc finger DHHC-type palmitoyltransferase 16aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1621
    See related
    Ensembl:ENSDARG00000007808 AllianceGenome:ZFIN:ZDB-GENE-040426-1621
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zdhhc16; DHHC-16A; zgc:66369
    Summary
    Predicted to enable palmitoyltransferase activity. Involved in telencephalon development. Acts upstream of or within fibroblast growth factor receptor signaling pathway involved in forebrain neuron fate commitment. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in Golgi apparatus. Is expressed in anterior neural plate; blastomere; forebrain; midbrain; and telencephalon. Orthologous to human ZDHHC16 (zinc finger DHHC-type palmitoyltransferase 16). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See zdhhc16a in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (31379784..31389680, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (31249334..31259211, complement)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene ribosomal RNA processing 12 homolog Neighboring gene ubiquitin domain containing 1a Neighboring gene methyltransferase 18, RPL3 N3-histidine Neighboring gene phosphoglycerate mutase 1a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. ZDHHC16 modulates FGF/ERK dependent proliferation of neural stem/progenitor cells in the zebrafish telencephalon. Shi W, et al. Dev Neurobiol, 2016 Sep. PMID 26663717
    2. 2-Bromopalmitate impairs neural stem/progenitor cell proliferation, promotes cell apoptosis and induces malformation in zebrafish embryonic brain. Wang C, et al. Neurotoxicol Teratol, 2015 Jul-Aug. PMID 26056731
    3. Protein palmitoylation activate zygotic gene expression during the maternal-to-zygotic transition. Du Z, et al. Biochem Biophys Res Commun, 2016 Jun 24. PMID 27235108
    4. Comprehensive expression map of transcription regulators in the adult zebrafish telencephalon reveals distinct neurogenic niches. Diotel N, et al. J Comp Neurol, 2015 Jun 1. PMID 25556858, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Clone Names

    • MGC66369

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables palmitoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables palmitoyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA damage response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within commitment of multipotent stem cells to neuronal lineage in forebrain IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in eye development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in fibroblast growth factor receptor signaling pathway involved in forebrain neuron fate commitment IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway involved in forebrain neuron fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heart development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in heart development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein palmitoylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in telencephalon development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    palmitoyltransferase ZDHHC16A
    Names
    probable palmitoyltransferase ZDHHC16
    zinc finger DHHC domain-containing protein 16A
    zinc finger DHHC-type containing 16a
    zinc finger, DHHC domain containing 16
    zinc finger, DHHC domain containing 16a
    NP_001349335.1
    NP_957336.2
    XP_017214210.1
    XP_068068920.1
    XP_068068921.1
    XP_068068922.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362406.1 → NP_001349335.1  palmitoyltransferase ZDHHC16A isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      BX072537
      Conserved Domains (1) summary
      pfam01529
      Location:151 → 277
      zf-DHHC; DHHC palmitoyltransferase

    2. NM_201042.2 → NP_957336.2  palmitoyltransferase ZDHHC16A isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BX072537
      UniProtKB/Swiss-Prot
      B8A4F0, Q7SXG0
      Related
      ENSDARP00000119367.1, ENSDART00000134630.3
      Conserved Domains (1) summary
      pfam01529
      Location:151 → 249
      zf-DHHC; DHHC palmitoyltransferase

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      31379784..31389680 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068212821.1 → XP_068068922.1  palmitoyltransferase ZDHHC16A isoform X4

    2. XM_068212819.1 → XP_068068920.1  palmitoyltransferase ZDHHC16A isoform X2

    3. XM_017358721.3 → XP_017214210.1  palmitoyltransferase ZDHHC16A isoform X1

      UniProtKB/TrEMBL
      A0A8M6Z1M7

    4. XM_068212820.1 → XP_068068921.1  palmitoyltransferase ZDHHC16A isoform X3

    RNA

    1. XR_011005840.1 RNA Sequence

    2. XR_011005843.1 RNA Sequence

    3. XR_011005842.1 RNA Sequence

    4. XR_011005841.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B8A4F0.1 GenPept UniProtKB/Swiss-Prot:B8A4F0

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